Matsumoto Isao, Nakashima Ko, Morita Hajime, Kasahara Koichi, Kataoka Osamu, Uchida Kazuyuki
Japan Small Animal Medical Center, Tokorozawa-shi, Saitama, Japan.
Laboratory of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan.
JFMS Open Rep. 2019 Mar 14;5(1):2055116919836537. doi: 10.1177/2055116919836537. eCollection 2019 Jan-Jun.
A 10-year-old castrated male domestic shorthair cat presented with a 6 month history of diarrhoea that responded poorly to medical treatment. Ultrasonography revealed moderate thickening of the colonic wall (4.8 mm) and right colic and jejunal lymphadenomegalies. Endoscopic examination revealed partial circumferential narrowing of the transverse colon and friable colonic mucosa with multiple haemorrhagic regions. Histopathological and immunohistochemical examinations revealed a large number of phagocytosed by periodic acid-Schiff-positive macrophages. Bacterial culture also yielded enrofloxacin-sensitive . The cat was initially treated with prednisolone, which resulted in little improvement. Following histopathological examination and bacterial culture, treatment with enrofloxacin was commenced. Antibacterial therapy resulted in remission of the diarrhoea and an increase in body weight within 14 days.
Granulomatous colitis (GC) or histiocytic ulcerative colitis has been rarely described in cats. There has only been one previously published case study involving a cat, and the aetiology remains largely unknown. The current article describes the regression of -related GC following antibacterial treatment in a cat. Clinical signs, histopathological appearance and response to enrofloxacin were similar to those in canine GC. The current findings suggest that also plays an important role in the development of feline GC.
一只10岁去势的雄性家猫出现腹泻6个月，药物治疗效果不佳。超声检查显示结肠壁中度增厚（4.8毫米），右结肠和空肠淋巴结肿大。内镜检查显示横结肠部分周向狭窄，结肠黏膜脆弱，有多个出血区域。组织病理学和免疫组织化学检查显示大量被高碘酸-希夫阳性巨噬细胞吞噬。细菌培养也产生了对恩诺沙星敏感的菌株。这只猫最初用泼尼松龙治疗，效果甚微。经过组织病理学检查和细菌培养后，开始用恩诺沙星治疗。抗菌治疗使腹泻缓解，体重在14天内增加。
肉芽肿性结肠炎（GC）或组织细胞性溃疡性结肠炎在猫中很少被描述。之前仅有一篇已发表的涉及猫的病例研究，病因在很大程度上仍不清楚。本文描述了一只猫在抗菌治疗后与[具体病因未提及]相关的GC的消退情况。临床症状、组织病理学表现和对恩诺沙星的反应与犬GC相似。目前的研究结果表明[具体病因未提及]在猫GC的发生中也起重要作用。
