Peyman Mohammadreza, Peyman Alireza, Lansingh Van C, Orandi Amirhossein, Subrayan Visvaraja
Parsian Vision Science Research Institute, Isfahan, Iran.
Department of Ophthalmology, Isfahan University of Medical Science, Isfahan, Iran.
J Curr Ophthalmol. 2018 Oct 30;31(1):55-60. doi: 10.1016/j.joco.2018.09.007. eCollection 2019 Mar.
To evaluate the effects of anti-vascular endothelial growth factors (anti-VEGF) on the vessels of the non-treated eyes following intravitreal injections.
In this prospective, non-randomized trial, a total of 38 patients were recruited. 21 patients received ranibizumab, and 17 patients received bevacizumab. Fundus photography was carried out at baseline immediately before injection and at 3 days, 7 days, and one month after the injections. Using image analysis software, measurements were summarized as the central retinal artery equivalent (CRAE) and central retinal vein equivalent.
In non-treated eyes, CRAE decreased significantly from 153.23 ± 15.20 μm before injection to 148.77 ± 17.21 μm 3 days after intravitreal bevacizumab ( = 0.004). There was no significant difference in CRAE, between the pre-injection baseline, one week, and one month after intravitreal bevacizumab injection in non-treated eyes ( > 0.05). No significant difference was noted in CRAE in the non-treated eyes of the ranibizumab group at any post-injection visit ( = 0.1).
A significant transient narrowing effect of bevacizumab on retinal arterioles in the fellow non-treated eyes on the third day after intravitreal injection may show that plasma concentrations of these drugs are sufficient to spread the effect to the other eye.
评估玻璃体内注射抗血管内皮生长因子（anti-VEGF）对未治疗眼血管的影响。
在这项前瞻性、非随机试验中，共招募了38名患者。21名患者接受雷珠单抗治疗，17名患者接受贝伐单抗治疗。在注射前的基线、注射后3天、7天和1个月进行眼底照相。使用图像分析软件，测量结果总结为视网膜中央动脉等效直径（CRAE）和视网膜中央静脉等效直径。
在未治疗眼中，玻璃体内注射贝伐单抗后3天，CRAE从注射前的153.23±15.20μm显著降至148.77±17.21μm（P = 0.004）。在未治疗眼中，玻璃体内注射贝伐单抗后，注射前基线、1周和1个月时的CRAE无显著差异（P>0.05）。在雷珠单抗组未治疗眼中，注射后任何时间点的CRAE均无显著差异（P = 0.1）。
玻璃体内注射贝伐单抗后第三天，对未治疗的对侧眼视网膜小动脉有显著的短暂缩窄作用，这可能表明这些药物的血浆浓度足以将作用扩散到另一只眼睛。
