新型基于聚硅氧烷的罗丹明 B 荧光探针用于选择性检测 Al 及其在活细胞和斑马鱼成像中的应用。
Novel polysiloxane-based rhodamine B fluorescent probe for selectively detection of Al and its application in living-cell and zebrafish imaging.
机构信息
Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong 250022, PR China.
Institute of Fluorescent Probes for Biological Imaging, School of Chemistry and Chemical Engineering, School of Materials Science and Engineering, University of Jinan, Shandong 250022, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2019 Jun 5;216:207-213. doi: 10.1016/j.saa.2019.01.093. Epub 2019 Mar 5.
Polysiloxanes have excellent stability and biological relevance and are suitable for biological research. However, there were few polysiloxane-based fluorescent probes for bioimaging. This report successfully designed a new polysiloxane-based polymer fluorescent probe (RB-1) for the first time as a "turn-on" fluorescent probe response to Al ion with highly sensitive and selectivity. Importantly, this probe could also apply both in cell and zebrafish imaging, indicating the huge application development prospects of polysiloxane-based fluorescent probes in future.
聚硅氧烷具有优异的稳定性和生物相关性，适合用于生物研究。然而，用于生物成像的基于聚硅氧烷的荧光探针却很少。本报告首次成功设计了一种新型基于聚硅氧烷的聚合物荧光探针（RB-1），它可作为一种“开启”型荧光探针，对 Al 离子具有高灵敏度和选择性的响应。重要的是，该探针还可以同时应用于细胞和斑马鱼成像，这表明基于聚硅氧烷的荧光探针在未来具有巨大的应用开发前景。
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