Department of Pharmaceutical Biology and Botany, Wroclaw Medical University, 50-367 Wrocław, Poland.
Department of Pharmacognosy and Molecular Foundations of Phytotherapy, Warsaw Medical University, 02-097 Warszawa, Poland.
Molecules. 2019 Mar 21;24(6):1136. doi: 10.3390/molecules24061136.
The rhizome of is a well-known traditional herb (Hu zhang) used in East Asia to treat various inflammatory diseases, infections, skin diseases, scald, and hyperlipidemia. It is also one of the richest natural sources of resveratrol. Although, it has been recently included in the European Pharmacopoeia, in Europe it is still an untapped resource. Some of the therapeutic effects are likely to be influenced by its antioxidant properties and this in turn is frequently associated with a high stilbene content. However, compounds other than stilbenes may add to the total antioxidant capacity. Hence, the aim of this research was to examine rhizomes of R. japonica and the less studied but morphologically similar species, and x for their phytochemical composition and antioxidant activity and to clarify the relationship between the antioxidant activity and the components by statistical methods. HPLC/UV/ESI-MS studies of three Reynoutria species revealed 171 compounds, comprising stilbenes, carbohydrates, procyanidins, flavan-3-ols, anthraquinones, phenylpropanoids, lignin oligomers, hydroxycinnamic acids naphthalenes and their derivatives. Our studies confirmed the presence of procyanidins with high degree of polymerization, up to decamers, in the rhizomes of and provides new data on the presence of these compounds in other species. A procyanidin trimer digallate was described for the first time in, the studied plants. Moreover, we tentatively identified dianthrone glycosides new for these species and previously unrecorded phenylpropanoid disaccharide esters and hydroxycinnamic acid derivatives. Furthermore, compounds tentatively annotated as lignin oligomers were observed for the first time in the studied species. The rhizomes of all species exhibited strong antioxidant activity. Statistical analysis demonstrated that proanthocyanidins should be considered as important contributors to the total antioxidant capacity.
是一种著名的传统草药（虎杖），在东亚被用于治疗各种炎症性疾病、感染、皮肤病、烫伤和高血脂。它也是白藜芦醇最丰富的天然来源之一。虽然它最近已被列入《欧洲药典》，但在欧洲它仍然是一种未被开发的资源。一些治疗效果可能与其抗氧化特性有关，而这又常常与高白藜芦醇含量有关。然而，除了白藜芦醇之外，其他化合物也可能增加总抗氧化能力。因此，本研究的目的是研究 、 和 根茎的化学成分和抗氧化活性，并通过统计方法阐明抗氧化活性与成分之间的关系。对三种 属植物的 HPLC/UV/ESI-MS 研究表明，有 171 种化合物，包括白藜芦醇、碳水化合物、原花青素、黄烷-3-醇、蒽醌、苯丙素、木质素低聚物、羟基肉桂酸萘及其衍生物。我们的研究证实了 和 根茎中存在聚合度高的原花青素，高达十聚体，并为这些化合物在其他 属植物中的存在提供了新的数据。首次在 中描述了三聚体儿茶素没食子酸酯。此外，我们还推测出这些植物中二蒽酮糖苷的存在，以及以前未记录的苯丙素二糖酯和羟基肉桂酸衍生物。此外，在研究的植物中，首次观察到了暂定标记为木质素低聚物的化合物。所有 属植物的根茎均表现出较强的抗氧化活性。统计分析表明，原花青素应被视为总抗氧化能力的重要贡献者。
