Martini A, Ravelli A, Notarangelo L D, Maccario R, Lanfranchi A, Rondena D, Ugazio A G, Burgio R
J Rheumatol. 1986 Jun;13(3):598-603.
Blood mononuclear cells from a total of 23 children with juvenile arthritis were stimulated in vitro to produce interleukin 1 (IL-1) and interleukin 2 (IL-2) and compared with age matched healthy controls. Peripheral blood monocytes from patients with juvenile arthritis produced a higher amount of IL-1 than controls, whereas peripheral blood lymphocytes from the same patients produced lower amount of IL-2 than controls. These findings could not be explained by concurrent therapy. The increase of IL-1 production was more marked in patients with active disease and therefore may have been secondary to the pathological process. However, the decrease of IL-2 production did not depend on disease activity, thus suggesting an immunoregulatory abnormality.
对总共23名青少年关节炎患儿的血液单核细胞进行体外刺激，以产生白细胞介素1（IL-1）和白细胞介素2（IL-2），并与年龄匹配的健康对照进行比较。青少年关节炎患者的外周血单核细胞产生的IL-1量高于对照组，而同一患者的外周血淋巴细胞产生的IL-2量低于对照组。这些发现无法用同时进行的治疗来解释。IL-1产生的增加在患有活动性疾病的患者中更为明显，因此可能继发于病理过程。然而，IL-2产生的减少并不取决于疾病活动，从而提示免疫调节异常。
