Gray K J, Engelmann U H, Johnson E H, Fishman I J
J Urol. 1986 Aug;136(2):497-500. doi: 10.1016/s0022-5347(17)44929-9.
Cyclophosphamide is a well established cytotoxic drug used in the treatment of lymphoproliferative disorders, certain solid tumors, and nonneoplastic disorders such as nephrotic syndrome, systemic lupus erythematosus and rheumatoid arthritis. Hemorrhagic cystitis can be a complication of this drug varying between two and 40 per cent. Misoprostol, which is a synthetic prostaglandin E1 analog, was found to significantly decrease the histological damage to the bladder from cyclophosphamide. Male rats receiving misoprostol in conjunction with cyclophosphamide were found to have a reduction in ulceration, inflammation and edema of the bladder walls as compared to those treated with cyclophosphamide alone.
环磷酰胺是一种成熟的细胞毒性药物，用于治疗淋巴增生性疾病、某些实体瘤以及肾病综合征、系统性红斑狼疮和类风湿性关节炎等非肿瘤性疾病。出血性膀胱炎可能是该药物的一种并发症，发生率在2%至40%之间。米索前列醇是一种合成的前列腺素E1类似物，已发现它能显著减少环磷酰胺对膀胱的组织学损伤。与单独接受环磷酰胺治疗的雄性大鼠相比，同时接受米索前列醇和环磷酰胺治疗的雄性大鼠膀胱壁的溃疡、炎症和水肿有所减轻。
