成人肌肉骨骼创伤人群中中枢敏化的测量及其测量特性：系统评价和数据综合的方案。

Measures of central sensitisation and their measurement properties in the adult musculoskeletal trauma population: a protocol for a systematic review and data synthesis.

机构信息

Centre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, College of Life and Environmental Sciences, University of Birmingham, Birmingham, UK.

出版信息

BMJ Open. 2019 Mar 23;9(3):e023204. doi: 10.1136/bmjopen-2018-023204.

DOI:10.1136/bmjopen-2018-023204

PMID:30904837

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6475353/

Abstract

INTRODUCTION

Pain following musculoskeletal trauma is common with poor outcomes and disability well documented. Pain is complex in nature and can include the four primary mechanisms of pain: nociceptive, neuropathic, inflammatory and central sensitisation (CS). CS can be measured in multiple ways; however, no systematic review has evaluated the measurement properties of such measures in the musculoskeletal trauma population. This systematic review aims to evaluate the measurement properties of current measures of CS in this population.

METHODS/ANALYSIS: This protocol is informed and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-P. MEDLINE, EMBASE, CINAHL, ZETOC, Web of Science, PubMed and Google Scholar as well as key journals and grey literature will be searched in two stages to (1) identify what measures are being used to assess CS in this population and (2) evaluate the measurement properties of the identified measures. Two independent reviewers will conduct the search, extract the data, assess risk of bias for included studies and assess overall quality. The Consensus-based Standards for the selection of Health Measurement Instruments Risk of Bias Checklist and a modified Grading of Recommendations, Assessment, Development and Evaluation guidelines will be used. Meta-analysis will be conducted if deemed appropriate. Alternatively, a narrative synthesis will be conducted and summarised per measurement property per outcome measure.

ETHICS AND DISSEMINATION

This review will aid clinicians in using the most appropriate tool for assessing central sensitisation in this population and is the first step towards a more standardised approach in pain assessment. The results of this study will be submitted to a peer reviewed journal and presented at conferences.

PROSPERO REGISTRATIONNUMBER

CRD42018091531.

摘要

简介

肌肉骨骼创伤后疼痛很常见，其不良后果和残疾有充分记录。疼痛性质复杂，可包括疼痛的四个主要机制：伤害性、神经性、炎症性和中枢敏化（CS）。CS 可以通过多种方式进行测量；然而，尚无系统评价评估 CS 此类测量方法在肌肉骨骼创伤人群中的测量特性。本系统评价旨在评估该人群中 CS 现有测量方法的测量特性。

方法/分析：本方案根据系统评价和荟萃分析的首选报告项目-P 通知并报告。将分两个阶段检索 MEDLINE、EMBASE、CINAHL、ZETOC、Web of Science、PubMed 和 Google Scholar 以及重点期刊和灰色文献，以（1）确定用于评估该人群中 CS 的测量方法，（2）评估所确定的测量方法的测量特性。两名独立审查员将进行搜索、提取数据、评估纳入研究的偏倚风险并评估总体质量。将使用共识标准选择健康测量仪器偏倚风险检查表和修改后的推荐评估、开发和评估指南进行分级。如果认为合适，将进行荟萃分析。或者，将进行叙述性综合，并按测量特性对每个测量结果进行总结。