Dunne M P, Hartley L R
Psychopharmacology (Berl). 1986;89(1):94-7. doi: 10.1007/BF00175197.
Recent work with humans and animals has suggested that the cholinergic system plays an important role in the active control of attention. This study was designed to investigate the effects of scopolamine upon subjects' ability to utilize knowledge of the spatial probability bias in a display in the detection of briefly-presented target letters. Results showed a significant interaction between drug condition (scopolamine 0.9 mg versus Placebo) and target location probability, which indicated that detection of targets in high probability locations decreased under the drug, while detection in low probability locations increased. These results offer support for the notion that scopolamine reduces the efficiency of information encoding because it impairs the optimal utilization of attentional resources.
近期针对人类和动物的研究表明，胆碱能系统在注意力的主动控制中发挥着重要作用。本研究旨在探究东莨菪碱对受试者利用显示屏中空间概率偏差知识来检测短暂呈现的目标字母能力的影响。结果显示，药物状态（0.9毫克东莨菪碱与安慰剂）和目标位置概率之间存在显著交互作用，这表明在药物作用下，高概率位置目标的检测率下降，而低概率位置目标的检测率上升。这些结果支持了以下观点：东莨菪碱降低了信息编码效率，因为它损害了注意力资源的最佳利用。
