1 Department of Medicine, University of California, San Francisco, California, USA.
2 Department of Neurology, University of California, San Francisco, California, USA.
Otolaryngol Head Neck Surg. 2019 Jul;161(1):28-35. doi: 10.1177/0194599819835178. Epub 2019 Mar 26.
Tinnitus is a condition that causes distress and impairment across cognitive, functional, and psychiatric spectra. In the psychiatric realm, tinnitus has long been associated with depression. To better characterize the co-occurrence of depression and tinnitus, we performed a systematic review of the prevalence of depression among patients with tinnitus.
We comprehensively examined original studies reporting the prevalence of depression in adult populations with tinnitus, as indexed in the PubMed and Web of Science databases and published from January 2006 to August 2016.
All identified articles were reviewed independently by 2 researchers, with a third reviewer for adjudication. Included studies were evaluated for threats to validity across 3 domains-representativeness, response rate, and ascertainment of outcome-on a 4-point modified Newcastle-Ottawa Quality Assessment Scale.
Twenty-eight studies were included, representing 15 countries and 9979 patients with tinnitus. Among the included studies, the median prevalence of depression was 33%, with an interquartile range of 19% to 49% and an overall range of 6% to 84%. Studies were high quality overall, with a mean score of 3.3 (SD = 0.76), and 89% utilized a validated tool to ascertain depression.
We conducted one of the largest contemporary comprehensive reviews, which suggests a 33% prevalence of depression among patients with tinnitus. Our review reaffirms that a substantial proportion of patients with tinnitus have depression, and we recommend that all who treat tinnitus should screen and treat their patients for depression, if present.
耳鸣是一种会导致认知、功能和精神障碍的病症。在精神医学领域，耳鸣长期以来与抑郁症相关。为了更好地描述耳鸣与抑郁症的共同发生情况，我们对耳鸣患者中抑郁症的患病率进行了系统回顾。
我们全面检索了 PubMed 和 Web of Science 数据库中 2006 年 1 月至 2016 年 8 月发表的关于成年耳鸣患者中抑郁症患病率的原始研究，并索引了这些研究。
由 2 名研究人员独立审查所有确定的文章，并由第 3 名评审员进行裁决。对纳入的研究从代表性、应答率和结局确定 3 个方面进行了 4 分制改良 Newcastle-Ottawa 质量评估量表评估。
共纳入 28 项研究，代表了 15 个国家的 9979 名耳鸣患者。纳入研究中，抑郁症的中位数患病率为 33%，四分位距为 19%至 49%，总体范围为 6%至 84%。研究整体质量较高，平均得分为 3.3（标准差=0.76），89%的研究使用了经过验证的工具来确定抑郁症。
我们进行了一次当代最大规模的综合回顾之一，表明耳鸣患者中抑郁症的患病率为 33%。我们的综述再次证实，相当一部分耳鸣患者患有抑郁症，我们建议所有治疗耳鸣的医生都应筛查并治疗存在的抑郁症状。
