College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials , Luoyang Normal University , Luoyang 471934 , P. R. China.
Key Laboratory of Theoretical Chemistry of Environment, Ministry of Education, School of Chemistry & Environment , South China Normal University , Guangzhou 510006 , P. R. China.
J Agric Food Chem. 2019 Apr 10;67(14):3871-3878. doi: 10.1021/acs.jafc.9b00164. Epub 2019 Apr 1.
Considerable interest in using lanthanide complexes in optics have been well-known persisted for a long time. But such molecular-based edifices have been excluded from practical application because of their poor thermal or photo stabilities. Here a novel europium embedded layered double hydroxide (Mg-Al LDH-Eu) has been established and such an inorganic-organic framework demonstrates improved thermal performance due to hydrolysis and poly condensation of the trimethoxysilyl-unit. In addition, the incorporation of a functional building block such as ethylenediamine triacetic acid can significantly minimize the negative effects of hydroxyl groups. In the presence of tetracycline (Tc), the nanoprobe exhibits an "off-on" change in aqueous solution, and the red luminescence can be excited in the visible light range (405 nm). It provides a very sensitive signal response to Tc with an excellent linear relation in the range of 0.1 μM to 5.0 μM, and the detection limit of this probe is measured to be 7.6 nM. This nanoplatform exhibits low cytotoxicity during in vitro experiments and can be employed for the detection of tetracycline in 293T cells.
人们对镧系配合物在光学方面的应用一直很感兴趣，并且这种兴趣由来已久。但是，由于这些基于分子的结构热稳定性或光稳定性差，它们被排除在实际应用之外。在这里，我们建立了一种新型的铕嵌入层状双氢氧化物（Mg-Al LDH-Eu），由于三甲氧基硅烷基单元的水解和缩聚，这种无机-有机框架表现出了改善的热性能。此外，引入功能基元（如乙二胺四乙酸）可以显著减少羟基的负面影响。在四环素（Tc）存在的情况下，纳米探针在水溶液中表现出“开-关”变化，并且可以在可见光范围内（405nm）激发红色发光。它对 Tc 表现出非常灵敏的信号响应，在 0.1μM 至 5.0μM 的范围内具有良好的线性关系，该探针的检测限测定为 7.6nM。该纳米平台在体外实验中表现出低细胞毒性，可用于 293T 细胞中环丙沙星的检测。
