Uhari M, Eskelinen L, Jokisalo J
Eur J Clin Pharmacol. 1986;30(4):503-4. doi: 10.1007/BF00607970.
The acceptance by children of two pharmacologically identical phenoxymethyl-penicillin potassium and erythromycin ethylsuccinate mixtures, differing only in their flavouring agents, was compared in a randomised blind manner. The time a nurse required to give the drug to a child was recorded and a score of the acceptance was given by the nurse. The mean time to give erythromycin Brand 1 was 29 s (SD +/- 21, number of children = 20) and mean time to give Brand 2 it was 16 s (SD +/- 13, n = 18); the difference was significant (p less than 0.05). The mean scores were 2.9 (SD +/- 0.6) and 3.4 (SD +/- 0.5), difference -0.5 (p less than 0.025). The difference between the two penicillin products was not significant. The time required to give a medicine was a useful way to compare the effect of different flavouring mixtures on the acceptance of drugs by infants and children.
以随机盲法比较了儿童对两种药理学上相同的苯氧甲基青霉素钾和琥乙红霉素混合物的接受情况，这两种混合物仅调味剂不同。记录护士给儿童喂药所需的时间，并由护士给出接受度评分。给1号品牌红霉素的平均时间为29秒（标准差±21，儿童数量=20），给2号品牌的平均时间为16秒（标准差±13，n=18）；差异具有统计学意义（p<0.05）。平均得分分别为2.9（标准差±0.6）和3.4（标准差±0.5），差异为-0.5（p<0.025）。两种青霉素产品之间的差异不显著。给药所需时间是比较不同调味混合物对婴幼儿药物接受度影响的一种有用方法。
