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1
Recombinant human gamma interferon inhibits simian malaria.重组人γ干扰素可抑制猴疟。
Infect Immun. 1986 Sep;53(3):628-30. doi: 10.1128/iai.53.3.628-630.1986.
2
The role of cytokines in malaria infection.细胞因子在疟疾感染中的作用。
Bull World Health Organ. 1990;68 Suppl(Suppl):138-44.
3
Human interferon-gamma protects rhesus monkeys against sporozoite-induced Plasmodium cynomolgi malaria infection.
J Interferon Res. 1988 Apr;8(2):201-6. doi: 10.1089/jir.1988.8.201.
4
Poly ICLC inhibits Plasmodium cynomolgi B malaria infection in rhesus monkeys.聚肌胞苷酸抑制恒河猴感染食蟹猴疟原虫B型疟疾。
J Interferon Cytokine Res. 1996 Jan;16(1):49-52. doi: 10.1089/jir.1996.16.49.
5
Effects of interferon in malaria infection.
Immunol Lett. 1990 Aug;25(1-3):53-7. doi: 10.1016/0165-2478(90)90091-4.
6
Sterile protection of monkeys against malaria after administration of interleukin-12.给予白细胞介素-12后猴子对疟疾的无菌保护作用。
Nat Med. 1997 Jan;3(1):80-3. doi: 10.1038/nm0197-80.
7
Inhibition of development of exoerythrocytic forms of malaria parasites by gamma-interferon.γ-干扰素对疟原虫红细胞外期发育的抑制作用。
Science. 1986 May 16;232(4752):881-4. doi: 10.1126/science.3085218.
8
Multistage multiantigen heterologous prime boost vaccine for Plasmodium knowlesi malaria provides partial protection in rhesus macaques.用于诺氏疟原虫疟疾的多阶段多抗原异源初免-加强疫苗在恒河猴中提供部分保护。
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Azithromycin: antimalarial profile against blood- and sporozoite-induced infections in mice and monkeys.阿奇霉素：对小鼠和猴子血液及子孢子诱导感染的抗疟作用
Exp Parasitol. 2000 Jan;94(1):8-14. doi: 10.1006/expr.1999.4465.

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Tomatine adjuvantation of protective immunity to a major pre-erythrocytic vaccine candidate of malaria is mediated via CD8+ T cell release of IFN-gamma.番茄碱对疟疾主要红细胞前期疫苗候选物的保护性免疫佐剂作用是通过CD8 + T细胞释放γ干扰素介导的。
J Biomed Biotechnol. 2010;2010:834326. doi: 10.1155/2010/834326. Epub 2010 Mar 11.
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Phase I trial of an alhydrogel adjuvanted hepatitis B core virus-like particle containing epitopes of Plasmodium falciparum circumsporozoite protein.含恶性疟原虫环子孢子蛋白表位的铝佐剂乙肝核心病毒样颗粒的I期试验
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A linear peptide containing minimal T- and B-cell epitopes of Plasmodium falciparum circumsporozoite protein elicits protection against transgenic sporozoite challenge.一种包含恶性疟原虫环子孢子蛋白最小T细胞和B细胞表位的线性肽可引发针对转基因子孢子攻击的保护作用。
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Immunity to liver stage malaria: considerations for vaccine design.肝脏期疟疾免疫：疫苗设计的考量
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DNA immunization by Plasmodium falciparum liver-stage antigen 3 induces protection against Plasmodium yoelii sporozoite challenge.恶性疟原虫肝期抗原3的DNA免疫诱导对约氏疟原虫子孢子攻击的保护作用。
Infect Immun. 2001 Feb;69(2):1202-6. doi: 10.1128/IAI.69.2.1202-1206.2001.

本文引用的文献

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Cytochemical Assay of Interferon Produced by Duck Hepatitis Virus.鸭肝炎病毒产生的干扰素的细胞化学测定。
Science. 1963 Feb 15;139(3555):595-6. doi: 10.1126/science.139.3555.595.
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History of recent researches on tissue phases of the malaria parasite at the London School of Hygiene and Tropical Medicine.
Trans R Soc Trop Med Hyg. 1951 Oct;45(2):175-88. doi: 10.1016/s0035-9203(51)90885-1.
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Primaquine sensitivity. Glucose-6-phosphate dehydrogenase deficiency: an inborn error of metabolism of medical and biological significance.伯氨喹敏感性。葡萄糖-6-磷酸脱氢酶缺乏症：一种具有医学和生物学意义的先天性代谢缺陷。
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Protection of mice against the intracellular bacterium Listeria monocytogenes by recombinant immune interferon.重组免疫干扰素对小鼠抗细胞内细菌单核细胞增生李斯特菌的保护作用。
Eur J Immunol. 1984 Oct;14(10):964-7. doi: 10.1002/eji.1830141019.
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Interferon-gamma inhibits growth of Coxiella burnetii in mouse fibroblasts.γ干扰素抑制伯氏考克斯体在小鼠成纤维细胞中的生长。
Infect Immun. 1984 Sep;45(3):781-3. doi: 10.1128/iai.45.3.781-783.1984.
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Inhibition of growth of Toxoplasma gondii in cultured fibroblasts by human recombinant gamma interferon.人重组γ干扰素对培养的成纤维细胞中弓形虫生长的抑制作用。
Infect Immun. 1984 May;44(2):211-6. doi: 10.1128/iai.44.2.211-216.1984.
7
Cloned mouse interferon-gamma inhibits the growth of Rickettsia prowazekii in cultured mouse fibroblasts.克隆的小鼠干扰素-γ可抑制普氏立克次体在培养的小鼠成纤维细胞中的生长。
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8
Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine.淋巴因子刺激的人单核吞噬细胞对细胞内杜氏利什曼原虫的杀伤作用。γ干扰素是激活淋巴因子的证据。
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9
Expression of human immune interferon cDNA in E. coli and monkey cells.人免疫干扰素cDNA在大肠杆菌和猴细胞中的表达。
Nature. 1982 Feb 11;295(5849):503-8. doi: 10.1038/295503a0.
10
Anti-malarial effect of interferon inducers at different stages of development of Plasmodium berghei in the mouse.干扰素诱导剂对小鼠体内伯氏疟原虫不同发育阶段的抗疟作用。
Nature. 1968 Nov 16;220(5168):710-1. doi: 10.1038/220710a0.

重组人γ干扰素可抑制猴疟。

Recombinant human gamma interferon inhibits simian malaria.

作者信息

Maheshwari R K, Czarniecki C W, Dutta G P, Puri S K, Dhawan B N, Friedman R M

出版信息

Infect Immun. 1986 Sep;53(3):628-30. doi: 10.1128/iai.53.3.628-630.1986.

DOI:10.1128/iai.53.3.628-630.1986
PMID:3091507
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC260838/
Abstract

Prophylactic treatment with 0.1 mg of human gamma interferon per kg (body weight) per day completely suppressed experimental infection with Plasmodium cynomolgi B sporozoites in rhesus monkeys. Treatment with lower doses partially suppressed this infection. Prophylactic treatment with human gamma interferon, however, had no protective effect against trophozoite-induced infection, suggesting that the interferon effect was limited to the exoerythrocytic stage of parasitic development.

摘要

每天每千克（体重）用0.1毫克人γ干扰素进行预防性治疗，可完全抑制恒河猴感染食蟹猴疟原虫B子孢子的实验性感染。用较低剂量治疗可部分抑制这种感染。然而，用人γ干扰素进行预防性治疗对滋养体诱导的感染没有保护作用，这表明干扰素的作用仅限于寄生虫发育的红细胞外期。