Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Noncommunicable Disease Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.
J Cell Physiol. 2019 Aug;234(10):17144-17158. doi: 10.1002/jcp.28488. Epub 2019 Mar 27.
Diabetes mellitus is a chronic metabolic disorder, resulting in high morbidity and mortality worldwide. Neuropathy, ocular diseases, kidney diseases, and cardiovascular disease are common complications of diabetes that threats the patient's life. Chrysin (CH), a natural flavonoid, has several pharmacological effects, including antioxidant, antiapoptotic, anti-inflammatory, and anticancer. Strong scientific documents indicated that chrysin may be effective for preventing and treating complications of diabetes in experimental models. The present study was designed to review the association between chrysin administration and diabetes complications by focusing on the possible molecular pathway. The findings indicate that chrysin has protective effects against diabetes outcomes by modulating oxidative stress, inflammation, and apoptosis in animal models. However, more clinical trial study should be done to clear the protective effects of chrysin in diabetic patients.
糖尿病是一种慢性代谢紊乱，在全球范围内导致高发病率和死亡率。神经病变、眼部疾病、肾脏疾病和心血管疾病是糖尿病的常见并发症，威胁着患者的生命。白杨素（CH）是一种天然类黄酮，具有多种药理作用，包括抗氧化、抗细胞凋亡、抗炎和抗癌作用。大量科学文献表明，白杨素可能对预防和治疗实验模型中的糖尿病并发症有效。本研究旨在通过关注可能的分子途径，综述白杨素给药与糖尿病并发症之间的关系。研究结果表明，白杨素通过调节动物模型中的氧化应激、炎症和细胞凋亡，对糖尿病结局具有保护作用。然而，还需要更多的临床试验研究来明确白杨素对糖尿病患者的保护作用。
