Ambelu Yitayal Amogne, Shiferaw Melashu Balew, Abebe Molla, Enawgaw Bamlaku
Department of Laboratory, College of Health Sciences, Debretabor University, Debre Tabor, Ethiopia.
4College of Medicine and Health Science, School of Biomedical and Laboratory Sciences, Department of Hematology & Immunohematology, University of Gondar, P.O. Box 196, Gondar, Ethiopia.
J Diabetes Metab Disord. 2018 Aug 9;17(2):117-121. doi: 10.1007/s40200-018-0347-5. eCollection 2018 Dec.
The incidence of cardiovascular disease due to thrombosis is 2-4 folds greater in diabetic patients. Prothrombin time, activated partial thromboplastin time and platelet count are hematological indices that give an insight into the coagulation status. Hence, this study aims to assess the coagulation status of type II diabetic patients.
A comparative cross-sectional study was conducted at Bahir Dar Felege Hiwot referral hospital, Northwest Ethiopia. A total of 40 treated type II diabetic, 40 untreated diabetics and 40 non-diabetic subjects were included. After taking informed consent, structured questionnaire was used to collect socio-demographic data. Following interview, 4 ml of blood was collected to determine PT, aPTT and platelet count of the three groups. The data were entered into SPSS version 20 and analyzed. One-way ANOVA was used to compare means of PT, aPTT and platelet count among the groups. A value less than 0.05 was considered as statistically significant.
The mean aPTT of non-diabetic, treated and untreated type II diabetic patient was 32.8 ± 4.12 s, 34.4 ± 5.3 s, and 25.42 ± 8.46 s, respectively. The proportion of untreated diabetic patients with normal PT, aPTT and platelet counts was 60.0%, 7.5 and 92.5%, respectively. There was a significant shortening of aPTT in untreated diabetic as compared to both treated and non-diabetic controls ( < 0.001).
Shortening of aPTT in untreated type II diabetic patients might be useful marker in patients with diabetes. Therefore, monitoring the aPTT in newly diagnosed diabetic patients is important.
糖尿病患者因血栓形成导致的心血管疾病发病率比非糖尿病患者高2至4倍。凝血酶原时间、活化部分凝血活酶时间和血小板计数是反映凝血状态的血液学指标。因此，本研究旨在评估II型糖尿病患者的凝血状态。
在埃塞俄比亚西北部的巴赫达尔费莱格希沃特转诊医院进行了一项比较性横断面研究。共纳入40例接受治疗的II型糖尿病患者、40例未接受治疗的糖尿病患者和40例非糖尿病受试者。在获得知情同意后，使用结构化问卷收集社会人口学数据。访谈后，采集4毫升血液以测定三组患者的凝血酶原时间、活化部分凝血活酶时间和血小板计数。数据录入SPSS 20版进行分析。采用单因素方差分析比较各组凝血酶原时间、活化部分凝血活酶时间和血小板计数的均值。P值小于0.05被认为具有统计学意义。
非糖尿病患者、接受治疗和未接受治疗的II型糖尿病患者的平均活化部分凝血活酶时间分别为32.8±4.12秒、34.4±5.3秒和25.42±8.46秒。未接受治疗的糖尿病患者凝血酶原时间、活化部分凝血活酶时间和血小板计数正常的比例分别为60.0%、7.5%和92.5%。与接受治疗的糖尿病患者和非糖尿病对照组相比，未接受治疗的糖尿病患者的活化部分凝血活酶时间显著缩短（P<0.001）。
未接受治疗的II型糖尿病患者活化部分凝血活酶时间缩短可能是糖尿病患者的一个有用标志物。因此，监测新诊断糖尿病患者的活化部分凝血活酶时间很重要。
