Cambien F, Warnet J M, Jacqueson A, Ducimetiere P, Richard J L, Claude J R
Circulation. 1987 Aug;76(2):266-71. doi: 10.1161/01.cir.76.2.266.
The relations between parental history of early myocardial infarction and plasma lipids and apoproteins have been examined in a population of 4045 middle-aged (20 to 60 years old) working men at the initial examination of the Paris Prospective Study 2. Subjects with a history of myocardial infarction, angina pectoris, or peripheral arterial disease or those treated with hypolipidemic drugs were excluded from the analysis. The numbers of subjects with a paternal or maternal history of early myocardial infarction were 123 and 30, respectively. After adjustment for age, cigarette consumption, alcohol consumption, and body mass index, subjects with parental history of myocardial infarction had higher levels of total cholesterol (p less than .01), low-density lipoprotein (LDL) cholesterol (p less than .01), and apoprotein B (APOB) (p less than .0001) and a lower level of high-density lipoprotein (HDL) cholesterol (p less than .05) than subjects with no parental history of myocardial infarction. On the other hand, apoprotein A1 (APOA1) and triglyceride levels were not different between the two groups. The ratios of HDL/total cholesterol and APOA1/APOB were also lower in presence of parental myocardial infarction (p less than .001 and p less than .01, respectively). When a discriminant analysis was performed, only APOB level was related to parental myocardial infarction. The results for paternal and maternal history were very similar and were grouped for the analysis. We conclude that part of the known relationship between parental history of myocardial infarction and coronary heart disease could be mediated by an increased APOB level.
在巴黎前瞻性研究2的初次检查中，对4045名年龄在20至60岁之间的中年在职男性进行了研究，以探讨父母早发心肌梗死病史与血脂及载脂蛋白之间的关系。分析排除了有心肌梗死、心绞痛或外周动脉疾病病史的受试者，以及接受过降血脂药物治疗的受试者。有父亲或母亲早发心肌梗死病史的受试者人数分别为123人和30人。在对年龄、吸烟量、饮酒量和体重指数进行调整后，有父母心肌梗死病史的受试者与无父母心肌梗死病史的受试者相比，总胆固醇水平更高（p<0.01）、低密度脂蛋白（LDL）胆固醇水平更高（p<0.01）、载脂蛋白B（APOB）水平更高（p<0.0001），而高密度脂蛋白（HDL）胆固醇水平更低（p<0.05）。另一方面，两组之间载脂蛋白A1（APOA1）和甘油三酯水平没有差异。在有父母心肌梗死病史的情况下，HDL/总胆固醇和APOA1/APOB的比值也更低（分别为p<0.001和p<0.01）。当进行判别分析时，只有APOB水平与父母心肌梗死病史有关。父亲和母亲病史的结果非常相似，分析时将其合并。我们得出结论，父母心肌梗死病史与冠心病之间已知关系的部分原因可能是APOB水平升高所致。
