Mao Xiangbing, Yang Qing, Chen Daiwen, Yu Bing, He Jun
Animal Nutrition Institute, Sichuan Agricultural University, No. 211, Gongpinghuimin Road, Wenjiang District, Chengdu 611130, China.
Key Laboratory of Animal Disease-Resistance Nutrition, Chinese Ministry of Education, Chengdu 611130, China.
Biomed Res Int. 2019 Feb 26;2019:5721585. doi: 10.1155/2019/5721585. eCollection 2019.
As a kind of antibacterial and antifungal preservative, benzoic acid is widely used in foods and feeds. Recently, many studies showed that it could improve the growth and health, which should, at least partially, be derived from the promotion of gut functions, including digestion, absorption, and barrier. Based on the similarity of gut physiology between human and pigs, many relative studies in which piglets and porcine intestinal epithelial cells were used as the models have been done. And the results showed that using appropriate benzoic acid levels might improve gut functions via regulating enzyme activity, redox status, immunity, and microbiota, but excess administration would lead to the damage of gut health through redox status. However, the further mechanisms that some intestinal physiological functions might be regulated are not well understood. The present review will, in detail, summarize the effect of benzoic acid on gut functions.
作为一种抗菌和抗真菌防腐剂，苯甲酸广泛应用于食品和饲料中。最近，许多研究表明，它可以促进生长和健康，这至少部分源于对肠道功能的促进，包括消化、吸收和屏障功能。基于人类和猪肠道生理学的相似性，已经进行了许多以仔猪和猪肠上皮细胞为模型的相关研究。结果表明，使用适当水平的苯甲酸可能通过调节酶活性、氧化还原状态、免疫力和微生物群来改善肠道功能，但过量使用会通过氧化还原状态导致肠道健康受损。然而，苯甲酸调节某些肠道生理功能的进一步机制尚不清楚。本综述将详细总结苯甲酸对肠道功能的影响。
