Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, and Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Nanhai Road 7, Qingdao, 266071, P. R. China.
College of Chemistry and Chemical Engineering, Hubei Normal University, Cihu Road 11, Huangshi, 435002, P. R. China.
Chem Biodivers. 2020 Nov;17(11):e2000566. doi: 10.1002/cbdv.202000566. Epub 2020 Nov 3.
The AcOEt extract of Artemisia argyi-derived fungus Trichoderma koningiopsis QA-3 showed potent inhibitory activity against pathogenic bacteria. Fractionation of the extract resulted in the isolation of three new polyketides (1-3) and two new terpenoids (4 and 5), together with three known metabolites (6-8). Their chemical structures were analyzed by NMR spectra, ECD, HR-ESI-MS or HR-EI-MS, optical rotation, and X-ray crystallographic data, as well as by comparison with literature reports. In the antibacterial assays, 3-hydroxyharziandione (4) showed potent activity against human pathogen Escherichia coli with an MIC value of 0.5 μg/mL, while 6-(3-hydroxypent-1-en-1-yl)-2H-pyran-2-one exhibited strong activity against marine-derived aquatic pathogen Micrococcus luteus with an MIC value of 1.0 μg/mL.
艾草真菌里氏木霉 AcOEt 提取物对致病菌具有很强的抑制活性。提取物的分级分离得到了三个新的聚酮化合物（1-3）和两个新的萜类化合物（4 和 5），以及三个已知的代谢物（6-8）。通过 NMR 光谱、ECD、HR-ESI-MS 或 HR-EI-MS、旋光和 X 射线晶体学数据以及与文献报道的比较，分析了它们的化学结构。在抑菌试验中，3-羟基哈兹酮（4）对人体病原菌大肠杆菌表现出很强的活性，MIC 值为 0.5μg/mL，而 6-（3-羟基戊-1-烯-1-基）-2H-吡喃-2-酮对海洋来源的水生病原菌微球菌表现出很强的活性，MIC 值为 1.0μg/mL。
