Eliashiv A, Olumide F, Norton L, Eiseman B
Arch Surg. 1978 Oct;113(10):1180-3. doi: 10.1001/archsurg.1978.01370220066011.
Parameters of cell-mediated and humoral-mediated immunity were measured in ten infection-free, insulin-dependent, controlled diabetic patients and in ten similar but nondiabetic patients awaiting elective operations. Tests performed included total and differential leukocyte counts, neutrophil reduction of nitroblue tetrazolium, mitogen response of lymphocyte to phytohemagglutinin, ratio of thymus-derived to bone marrow-derived lymphocytes, serum immunoglobulins IgA, IgG, and IgM, macrophage inhibition factor, serum zinc, and reaction to skin test antigens. Diabetics had a significantly (P less than .05) decreased mean response response to phytoheagglutinin stimulation and a lowered ratio of thymus-derived to bone marrow-derived lymphocytes. These findings support the concept of depressed cell-mediated immunity in the controlled, adult diabetic and might explain the propensity of the uncontrolled diabetic to increased frequency and severity of bacterial infection.
对10名无感染、胰岛素依赖型且病情得到控制的糖尿病患者以及10名情况类似但等待择期手术的非糖尿病患者进行了细胞介导免疫和体液介导免疫参数的测量。所进行的检测包括白细胞总数及分类计数、中性粒细胞对硝基蓝四唑的还原能力、淋巴细胞对植物血凝素的有丝分裂反应、胸腺来源淋巴细胞与骨髓来源淋巴细胞的比例、血清免疫球蛋白IgA、IgG和IgM、巨噬细胞抑制因子、血清锌以及对皮肤试验抗原的反应。糖尿病患者对植物血凝素刺激的平均反应显著降低（P小于0.05），且胸腺来源淋巴细胞与骨髓来源淋巴细胞的比例降低。这些发现支持了成年糖尿病患者细胞介导免疫功能低下的概念，并可能解释了未得到控制的糖尿病患者细菌感染频率增加和病情加重的倾向。
