Rostami Hamzeh, Babaali Farzaneh, Moradi Leila, Golfakhrabadi Fereshteh, Abdi Leila
Department of Psychiatry, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Diabetes Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Iran J Psychiatry. 2023 Jul;18(3):362-368. doi: 10.18502/ijps.v18i3.13015.
Metabolic syndrome is a potential side effect of atypical antipsychotics which are the current standard treatment for schizophrenia. Therefore, we aimed to examine the effect of barberry root (Berberis vulgaris) on the prevention of metabolic syndrome caused by atypical antipsychotic drugs in patients with schizophrenia. Our research was a three-blind randomized clinical trial. The participants included all patients who were diagnosed with schizophrenia through the SCID-5 questionnaire and based on the DSM-5-TR criteria by two psychiatric experts. These patients were randomly divided into intervention and placebo groups. During a three-month treatment period, the intervention group received three 500 mg capsules of barberry root extract daily, whereas the placebo group received the same capsules containing 500 mg of starch powder. Metabolic syndrome variables including fasting blood glucose, serum lipids (triglyceride and cholesterol), blood pressure, weight and waist circumference were measured before and after the treatment as outcome measure. Chi-square and t-tests were used for data analysis using SPSS-22 software. At the beginning of the study, there was no significant difference between the intervention group (n = 41) and the placebo group (n = 47) in terms of demographic factors, and pre-treatment assessments including weight, waist size, fasting blood HDL, fasting blood triglycerides and systolic and diastolic blood pressure and fasting blood glucose (P > 0.05). Within group analysis showed that some metabolic factors significantly increased in both groups after the treatment (P < 0.05). Indeed, in both groups, metabolic syndrome measures worsened after the three-month treatment period. The parameters of weight and waist size were significantly higher in the intervention group than the placebo group after treatment (P < 0.05). Barberry root extract was not able to control the Effects of antipsychotic drugs on metabolic syndrome in schizophrenia.
代谢综合征是目前治疗精神分裂症的标准药物非典型抗精神病药物的潜在副作用。因此，我们旨在研究小檗根（普通小檗）对预防精神分裂症患者非典型抗精神病药物所致代谢综合征的作用。我们的研究是一项三盲随机临床试验。参与者包括所有通过SCID-5问卷并根据DSM-5-TR标准由两名精神科专家诊断为精神分裂症的患者。这些患者被随机分为干预组和安慰剂组。在为期三个月的治疗期间，干预组每天服用三粒500毫克的小檗根提取物胶囊，而安慰剂组服用含有500毫克淀粉粉末的相同胶囊。治疗前后测量代谢综合征变量，包括空腹血糖、血脂（甘油三酯和胆固醇）、血压、体重和腰围，作为结局指标。使用SPSS-22软件进行卡方检验和t检验进行数据分析。在研究开始时，干预组（n = 41）和安慰剂组（n = 47）在人口统计学因素以及治疗前评估（包括体重、腰围、空腹血高密度脂蛋白、空腹血甘油三酯、收缩压和舒张压以及空腹血糖）方面没有显著差异（P > 0.05）。组内分析表明，两组治疗后一些代谢因素均显著增加（P < 0.05）。事实上，在为期三个月的治疗期后，两组的代谢综合征指标均恶化。治疗后，干预组的体重和腰围参数显著高于安慰剂组（P < 0.05）。小檗根提取物无法控制抗精神病药物对精神分裂症患者代谢综合征的影响。
