Volk H D, Koyka I, Goan S R, Gruner S, Fiebig H, Sönnichsen N, Diezel W
J Invest Dermatol. 1986 Oct;87(4):524-7. doi: 10.1111/1523-1747.ep12455607.
Psoriatic patients have a decreased proportion of monocytes expressing class II major histocompatibility complex antigens (DR+ monocytes) in their peripheral blood. The expression of the DR antigen on monocytes after culture in the presence of either autologous lymphocytes (endogenous interferon-gamma, IFN-gamma) or exogenous IFN-gamma was investigated. In normal AB serum the lymphocytes of the majority of the patients showed a spontaneous IFN-gamma production which was sufficient for DR antigen induction, while the monocytes displayed approximate normal susceptibility to exogenous IFN-gamma as judged by DR antigen expression. However, the sera of psoriatic patients contained one or more factors that interfered with the IFN-gamma-mediated DR antigen expression on cultured monocytes of the same patients. Restoration of IFN-gamma-induced DR antigen expression on monocytes in the presence of the patient's sera was achieved by the addition of superoxide dismutase, 2-mercaptoethanol, or indomethacin. The clinical significance of these observations is discussed.
银屑病患者外周血中表达II类主要组织相容性复合体抗原的单核细胞（DR + 单核细胞）比例降低。研究了在自体淋巴细胞（内源性干扰素 - γ，IFN - γ）或外源性IFN - γ存在下培养后单核细胞上DR抗原的表达。在正常AB血清中，大多数患者的淋巴细胞表现出自发性IFN - γ产生，这足以诱导DR抗原，而根据DR抗原表达判断，单核细胞对外源性IFN - γ表现出近似正常的敏感性。然而，银屑病患者的血清含有一种或多种干扰同一患者培养单核细胞上IFN - γ介导的DR抗原表达的因子。通过添加超氧化物歧化酶、2 - 巯基乙醇或吲哚美辛，可在患者血清存在的情况下恢复IFN - γ诱导的单核细胞上DR抗原的表达。讨论了这些观察结果的临床意义。
