Vucijak-Grgurevic Marina, Zvizdic Faris, Durak-Nalbantic Azra, Jahic Elmedina, Resic Nerma, Huskic Jasminko
Department for Cardiology, Clinic for Heart, Blood Vessel and Rheumatic Diseases. University Clinical Center Sarajevo, Sarajevo, Bosnia and Herzegovina.
Departmant for Physiology, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
Mater Sociomed. 2018 Dec;30(4):246-250. doi: 10.5455/msm.2018.30.246-250.
An increase in nitric oxide (NO) synthesis concentration could help alleviate some pathological changes directly related to uremia.
To investigate the concentration of nitric oxide in saliva of patients with terminal stage of chronic renal failure on hemodialysis and to investigate the effect of hemodialysis on concentration of nitric oxide in saliva of the patients with terminal stage of chronic renal failure on hemodialysis.
The study had a prospective character and included 60 respondents of both sexes, at age between 20 and 60 years. The control group included 30 healthy volunteers of both sexes (15 men and 15 women) of the same age, who were based on subjective and objective health status without any manifestations of pathophysiological changes. The group of patients with terminal stage of chronic renal failure on hemodialysis involved 30 patients of both sexes (15 men and 15 women). Inclusion criteria: hemodialysis duration more than 6 months and age between 20 and 60 years.
The amount of non-stimulated saliva collected during 15 minutes in patients with chronic renal failure was lower by 31.3% compared to the control group of healthy subjects (p<0.0001). Concentration of NO in saliva in patients with chronic renal failure was higher by 121% than in the control group (p<0.001). Concentration of NO in saliva in patients with chronic renal failure after hemodialysis was 121% lower than in the same subjects prior to hemodialysis (p<0.001). A statistically significant negative correlation (r=-0.381, p<0.05) was found between the hemodialysis duration in months and the level of NO in saliva of the patients with chronic renal failure prior to hemodialysis. There was no statistically significant correlation (r=-0.167, NS) between the hemodialysis duration in months and NO levels in saliva of the patients with chronic renal failure after hemodialysis treatment.
Concentration of NO in saliva of the patients on hemodialysis was statistically significantly higher in relation to NO concentration in the saliva of healthy subjects and after hemodialysis was statistically significantly lower in relation to NO values prior to hemodialysis. Monitoring of changes in NO concentration dynamics in saliva of hemodialysis patients will probably be helpful in monitoring hemodialysis efficacy.
一氧化氮（NO）合成浓度的增加有助于缓解一些与尿毒症直接相关的病理变化。
研究维持性血液透析的慢性肾衰竭终末期患者唾液中一氧化氮的浓度，并探讨血液透析对维持性血液透析的慢性肾衰竭终末期患者唾液中一氧化氮浓度的影响。
本研究为前瞻性研究，纳入60名年龄在20至60岁之间的男女受访者。对照组包括30名年龄相同的健康志愿者（15名男性和15名女性），根据主观和客观健康状况，无任何病理生理变化表现。维持性血液透析的慢性肾衰竭终末期患者组包括30名男女患者（15名男性和15名女性）。纳入标准：血液透析时间超过6个月，年龄在20至60岁之间。
慢性肾衰竭患者15分钟内收集的非刺激性唾液量比健康受试者对照组低31.3%（p<0.0001）。慢性肾衰竭患者唾液中NO浓度比对照组高121%（p<0.001）。血液透析后慢性肾衰竭患者唾液中NO浓度比透析前同一受试者低121%（p<0.001）。慢性肾衰竭患者透析前，以月为单位的血液透析时间与唾液中NO水平之间存在统计学显著负相关（r=-0.381，p<0.05）。血液透析治疗后，以月为单位的血液透析时间与慢性肾衰竭患者唾液中NO水平之间无统计学显著相关性（r=-0.167，无显著性差异）。
维持性血液透析患者唾液中NO浓度与健康受试者唾液中NO浓度相比，在统计学上显著更高，而血液透析后与透析前的NO值相比，在统计学上显著更低。监测血液透析患者唾液中NO浓度动态变化可能有助于监测血液透析疗效。
