School of Exercise and Health, Shanghai University of Sport, Shanghai, China.
Physical Education College, Henan Sport University, Zhengzhou, China.
Front Endocrinol (Lausanne). 2024 Sep 3;15:1408466. doi: 10.3389/fendo.2024.1408466. eCollection 2024.
To investigate the molecular mechanisms through which exercise influences metabolic syndrome (MS) and identify key research trends and collaborative networks using bibliometric and visualization techniques.
We conducted a systematic literature search using the Web of Science Core Collection for articles published from 2014 to 2023. Using CiteSpace, we performed a bibliometric analysis of 562 eligible papers, generating visual knowledge maps to identify prevailing patterns, popular subjects, and emerging trends in the literature.
The study reveals that exercise mitigates MS by reversing high-fat diet-induced abdominal obesity, reducing lipid accumulation and inflammation, enhancing insulin sensitivity, and improving cardiovascular function. Key molecular pathways include PPAR-γ/CPT-1/MCAD signaling, AMPK activation, and nitric oxide production. The USA leads in research output, with significant contributions from American institutions. Collaboration among researchers is limited, highlighting the need for more extensive and high-quality research initiatives.
Regular, moderate-to-high-intensity exercise is crucial for managing MS. Exercise activates beneficial molecular pathways, improving metabolic health and cardiovascular function. Future research should focus on expanding collaborations and exploring novel molecular targets to enhance the therapeutic potential of exercise in metabolic syndrome management.
通过探讨运动影响代谢综合征（MS）的分子机制，利用文献计量学和可视化技术，确定关键的研究趋势和合作网络。
我们使用 Web of Science 核心合集，对 2014 年至 2023 年发表的文章进行了系统的文献检索。使用 CiteSpace，我们对 562 篇合格论文进行了文献计量分析，生成了可视化知识图谱，以识别文献中的主流模式、热门主题和新兴趋势。
研究表明，运动通过逆转高脂肪饮食引起的腹部肥胖、减少脂质积累和炎症、增强胰岛素敏感性以及改善心血管功能来缓解 MS。关键的分子途径包括 PPAR-γ/CPT-1/MCAD 信号、AMPK 激活和一氧化氮产生。美国在研究成果方面处于领先地位，美国机构做出了重大贡献。研究人员之间的合作有限，这表明需要开展更多广泛和高质量的研究计划。
有规律的、中高强度的运动对管理 MS 至关重要。运动激活有益的分子途径，改善代谢健康和心血管功能。未来的研究应侧重于扩大合作，并探索新的分子靶点，以提高运动在代谢综合征管理中的治疗潜力。
