Mardin Christian Y, Hosari Sami
Universitätsaugenklinik Erlangen, FAU Erlangen-Nürnberg, 91054, Erlangen, Deutschland.
Ophthalmologe. 2019 Aug;116(8):714-721. doi: 10.1007/s00347-019-0883-5.
Optical coherence tomography angiography (OCTA) enables a noninvasive detailed imaging of retinal and choroidal vessels of the fundus. In neuronal diseases changes in retinal structures can be imaged and measured with OCT and OCTA.
Can OCTA be used in neuronal diseases?
Evaluation of recent scientific articles and studies extracted from Medline on the topic of OCTA and neuronal diseases.
It could be shown that Alzheimer type dementia, Parkinson's disease, multiple sclerosis. cerebral infarction and CADASIL are neuronal diseases with rarification of retinal vessels and atrophy of the retinal layers in the ocular fundus.
These findings are beyond all changes which can be appreciated with ophthalmoscopy and OCTA parameters could serve in the future as supplementary biomarkers for assessment of the retinal-neurovascular coupling in these diseases.
光学相干断层扫描血管造影（OCTA）能够对眼底视网膜和脉络膜血管进行无创的详细成像。在神经疾病中，视网膜结构的变化可用光学相干断层扫描（OCT）和光学相干断层扫描血管造影（OCTA）进行成像和测量。
OCTA能否用于神经疾病？
对从医学在线数据库（Medline）中提取的有关OCTA和神经疾病主题的近期科学文章和研究进行评估。
结果表明，阿尔茨海默型痴呆、帕金森病、多发性硬化症、脑梗死和伴有皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病（CADASIL）是眼底视网膜血管稀疏和视网膜层萎缩的神经疾病。
这些发现超出了眼底镜检查所能观察到的所有变化，OCTA参数未来可能作为补充生物标志物用于评估这些疾病中的视网膜-神经血管耦合。
