a Department of Gynecology , Harbin Medical University Cancer Hospital , Harbin , Heilongjiang , China.
b Department of Cell Biology , Harbin Medical University , Harbin , Heilongjiang , China.
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):1224-1233. doi: 10.1080/21691401.2019.1593999.
In this study, we identified hsa_circ_0051240 was significantly increased in ovarian cancer (OC) tissues. Our results indicated that silencing of hsa_circ_0051240 inhibited OC cell proliferation, migration and invasion in vitro, and also prevented OC tumour formation in vivo. In addition, the inhibitory effects by blockage of hsa_circ_0051240 could be attenuated by the miR-637 inhibitor. Furthermore, we also identified that hsa_circ_0051240 act as a sponge of miR-637, and miR-637 directly targeted KLK4 mRNA in OC cells. Altogether, hsa_circ_0051240 promotes OC cell proliferation, migration and invasion through inhibiting the miR-637/KLK4 axis. Therefore, these results demonstrated that the hsa_circ_0051240/miR-637/KLK4 axis might serve as a therapeutic target for OC treatment.
在这项研究中，我们发现 hsa_circ_0051240 在卵巢癌 (OC) 组织中显著升高。我们的结果表明，沉默 hsa_circ_0051240 可抑制 OC 细胞在体外的增殖、迁移和侵袭，同时还可防止 OC 肿瘤在体内形成。此外，hsa_circ_0051240 阻断的抑制作用可被 miR-637 抑制剂减弱。此外，我们还发现 hsa_circ_0051240 可作为 miR-637 的海绵，并且 miR-637 可直接靶向 OC 细胞中的 KLK4 mRNA。总之，hsa_circ_0051240 通过抑制 miR-637/KLK4 轴促进 OC 细胞的增殖、迁移和侵袭。因此，这些结果表明 hsa_circ_0051240/miR-637/KLK4 轴可能作为 OC 治疗的治疗靶点。
