Bucknall C A, Morris G K, Mitchell J R
Br Med J (Clin Res Ed). 1986 Sep 20;293(6549):739-42. doi: 10.1136/bmj.293.6549.739.
A questionnaire was completed by 341 senior physicians on their attitudes to four common cardiovascular problems. Their replies showed that uncertainty about the end point for diastolic blood pressure still prevails and that their approach to the management of hypertension of differing severity in men and women of varying ages stems more from personal belief than from the results of clinical trials. Unless patients with atrial fibrillation also had mitral valve disease anticoagulation was not thought to be necessary, thereby making it ethically possible to carry out a trial of anticoagulants in stroke prevention on patients with atrial fibrillation but no valvular disease. The physicians' suggestions for very active management in transient ischaemic attacks extended beyond the evidence available to them, whereas their approach to the use of coronary arteriography closely reflected the results of clinical trials. These findings may indicate that recent cardiovascular trials that have provided definitive results have had more impact than earlier inadequate studies.
341名资深医生填写了一份关于他们对四种常见心血管问题态度的调查问卷。他们的回答表明,对于舒张压终点的不确定性仍然存在,而且他们针对不同年龄的男性和女性不同严重程度高血压的管理方法更多地源于个人信念,而非临床试验结果。除非房颤患者同时患有二尖瓣疾病,否则认为无需进行抗凝治疗,从而在伦理上使得对无瓣膜疾病的房颤患者进行预防中风的抗凝剂试验成为可能。医生们对短暂性脑缺血发作采取非常积极治疗的建议超出了他们所掌握的证据范围,而他们使用冠状动脉造影的方法则密切反映了临床试验结果。这些发现可能表明,近期提供了明确结果的心血管试验比早期不充分的研究产生了更大的影响。