Berger M R, Schmähl D
Cancer Lett. 1986 Sep;32(3):313-21. doi: 10.1016/0304-3835(86)90184-9.
This study describes the prolonged survival of male SD-rats that bear bladder carcinomas induced either with 44 mg/kg or 28 mg/kg of N-nitroso-N-butyl-N-(4-hydroxybutyl)amine (BBNOH), when daily doses of 350 mg/kg of sodium-2-mercaptoethane sulfonate (mesna) were administered concomitantly. The difference to carcinogen-treated positive controls was highly significant (P = 0.0009 and 0.0013, respectively). Tumor volumes at time of death (P less than 0.005) and frequency of metastases were also reduced in rats that received both compounds in comparison to BBNOH-treated animals.
本研究描述了雄性SD大鼠在膀胱被44mg/kg或28mg/kg的N-亚硝基-N-丁基-N-(4-羟基丁基)胺（BBNOH）诱导产生癌瘤后，同时每日给予350mg/kg的2-巯基乙烷磺酸钠（美司钠）时的长期存活情况。与接受致癌物处理的阳性对照组相比，差异极为显著（P值分别为0.0009和0.0013）。与仅接受BBNOH处理的动物相比，同时接受两种化合物处理的大鼠在死亡时的肿瘤体积（P<0.005）和转移频率也有所降低。
