Tacchi A M, Schmähl D, Habs M
Cancer Lett. 1984 Feb;22(1):89-94. doi: 10.1016/0304-3835(84)90048-x.
The influence of sodium-2-mercaptoethanesulphonate (Mesna) on urinary bladder cancer induced by N-nitroso-N-butyl-N-(4-hydroxybutyl)amine (BBNOH) was studied in male Sprague-Dawley rats. The treatment consisted of 5 g/kg BBNOH per gavage and 63 g/kg Mesna in drinking water over a period of 39 weeks. A positive control group was given the same dose of BBNOH as the treated group. Although Mesna did not reduce the incidence of bladder carcinomas, it significantly increased the lifespan of the animals, thus suggesting a partial general protective action.
在雄性斯普拉格-道利大鼠中研究了2-巯基乙烷磺酸钠（美司钠）对N-亚硝基-N-丁基-N-（4-羟基丁基）胺（BBNOH）诱导的膀胱癌的影响。治疗方案为：每周经口灌胃给予5 g/kg BBNOH，并在饮水中添加63 g/kg美司钠，持续39周。阳性对照组给予与治疗组相同剂量的BBNOH。尽管美司钠并未降低膀胱癌的发病率，但它显著延长了动物的寿命，因此提示其具有部分全身性保护作用。
