Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA 02114, USA.
http://exRNA.org/.
Cell. 2019 Apr 4;177(2):231-242. doi: 10.1016/j.cell.2019.03.023.
The Extracellular RNA Communication Consortium (ERCC) was launched to accelerate progress in the new field of extracellular RNA (exRNA) biology and to establish whether exRNAs and their carriers, including extracellular vesicles (EVs), can mediate intercellular communication and be utilized for clinical applications. Phase 1 of the ERCC focused on exRNA/EV biogenesis and function, discovery of exRNA biomarkers, development of exRNA/EV-based therapeutics, and construction of a robust set of reference exRNA profiles for a variety of biofluids. Here, we present progress by ERCC investigators in these areas, and we discuss collaborative projects directed at development of robust methods for EV/exRNA isolation and analysis and tools for sharing and computational analysis of exRNA profiling data.
细胞外 RNA 交流联合会（ERCC）的成立旨在加速细胞外 RNA（exRNA）生物学这一新领域的发展，并确定 exRNA 及其载体（包括细胞外囊泡（EVs））是否可以介导细胞间通讯，并用于临床应用。ERCC 的第一阶段重点关注 exRNA/EV 的生物发生和功能、exRNA 生物标志物的发现、基于 exRNA/EV 的治疗方法的开发，以及为各种生物流体构建一套强大的参考 exRNA 图谱。在这里，我们展示了 ERCC 研究人员在这些领域的进展，并讨论了旨在开发用于 EV/exRNA 分离和分析的稳健方法以及用于 exRNA 分析数据共享和计算分析的工具的合作项目。
