细胞外RNA通讯联盟的第二阶段绘制了细胞外RNA研究的下一代方法。
Phase 2 of extracellular RNA communication consortium charts next-generation approaches for extracellular RNA research.
作者信息
Mateescu Bogdan, Jones Jennifer C, Alexander Roger P, Alsop Eric, An Ji Yeong, Asghari Mohammad, Boomgarden Alex, Bouchareychas Laura, Cayota Alfonso, Chang Hsueh-Chia, Charest Al, Chiu Daniel T, Coffey Robert J, Das Saumya, De Hoff Peter, deMello Andrew, D'Souza-Schorey Crislyn, Elashoff David, Eliato Kiarash R, Franklin Jeffrey L, Galas David J, Gerstein Mark B, Ghiran Ionita H, Go David B, Gould Stephen, Grogan Tristan R, Higginbotham James N, Hladik Florian, Huang Tony Jun, Huo Xiaoye, Hutchins Elizabeth, Jeppesen Dennis K, Jovanovic-Talisman Tijana, Kim Betty Y S, Kim Sung, Kim Kyoung-Mee, Kim Yong, Kitchen Robert R, Knouse Vaughan, LaPlante Emily L, Lebrilla Carlito B, Lee L James, Lennon Kathleen M, Li Guoping, Li Feng, Li Tieyi, Liu Tao, Liu Zirui, Maddox Adam L, McCarthy Kyle, Meechoovet Bessie, Maniya Nalin, Meng Yingchao, Milosavljevic Aleksandar, Min Byoung-Hoon, Morey Amber, Ng Martin, Nolan John, De Oliveira Junior Getulio P, Paulaitis Michael E, Phu Tuan Anh, Raffai Robert L, Reátegui Eduardo, Roth Matthew E, Routenberg David A, Rozowsky Joel, Rufo Joseph, Senapati Satyajyoti, Shachar Sigal, Sharma Himani, Sood Anil K, Stavrakis Stavros, Stürchler Alessandra, Tewari Muneesh, Tosar Juan P, Tucker-Schwartz Alexander K, Turchinovich Andrey, Valkov Nedyalka, Van Keuren-Jensen Kendall, Vickers Kasey C, Vojtech Lucia, Vreeland Wyatt N, Wang Ceming, Wang Kai, Wang ZeYu, Welsh Joshua A, Witwer Kenneth W, Wong David T W, Xia Jianping, Xie Ya-Hong, Yang Kaichun, Zaborowski Mikołaj P, Zhang Chenguang, Zhang Qin, Zivkovic Angela M, Laurent Louise C
机构信息
Brain Research Institute, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland.
Institute for Chemical and Bioengineering, ETH Zürich, Vladimir Prelog Weg 1, 8093 Zürich, Switzerland.
出版信息
iScience. 2022 Jun 23;25(8):104653. doi: 10.1016/j.isci.2022.104653. eCollection 2022 Aug 19.
The extracellular RNA communication consortium (ERCC) is an NIH-funded program aiming to promote the development of new technologies, resources, and knowledge about exRNAs and their carriers. After Phase 1 (2013-2018), Phase 2 of the program (ERCC2, 2019-2023) aims to fill critical gaps in knowledge and technology to enable rigorous and reproducible methods for separation and characterization of both bulk populations of exRNA carriers and single EVs. ERCC2 investigators are also developing new bioinformatic pipelines to promote data integration through the exRNA atlas database. ERCC2 has established several Working Groups (Resource Sharing, Reagent Development, Data Analysis and Coordination, Technology Development, nomenclature, and Scientific Outreach) to promote collaboration between ERCC2 members and the broader scientific community. We expect that ERCC2's current and future achievements will significantly improve our understanding of exRNA biology and the development of accurate and efficient exRNA-based diagnostic, prognostic, and theranostic biomarker assays.
细胞外RNA通讯联盟（ERCC）是一项由美国国立卫生研究院资助的项目，旨在推动有关细胞外RNA（exRNA）及其载体的新技术、资源和知识的发展。在第一阶段（2013 - 2018年）之后，该项目的第二阶段（ERCC2，2019 - 2023年）旨在填补知识和技术上的关键空白，以实现用于分离和表征大量exRNA载体群体和单个细胞外囊泡（EV）的严格且可重复的方法。ERCC2的研究人员还在开发新的生物信息学管道，以通过exRNA图谱数据库促进数据整合。ERCC2已成立了几个工作组（资源共享、试剂开发、数据分析与协调、技术开发、命名法和科学推广），以促进ERCC2成员与更广泛的科学界之间的合作。我们预计，ERCC2目前和未来的成果将显著提高我们对exRNA生物学的理解，以及基于exRNA的准确、高效的诊断、预后和治疗诊断生物标志物检测方法的发展。
Zotero 插件