Department of Neuroscience, Psychology and Behaviour, University of Leicester, University Road, Leicester, LE1 7RH, UK.
Muthanna University, Samawah, Iraq.
Psychopharmacology (Berl). 2018 Mar;235(3):829-836. doi: 10.1007/s00213-017-4801-8. Epub 2017 Dec 2.
In rodents, sucrose has been found to elicit addictive-like behaviours like the development of tolerance and the association with cues present at the time of consumption. Furthermore, the neurochemical response to sucrose binges is equivalent to the one observed in response to the abuse of addictive substances like cocaine. The experiments reported here address the effects of sucrose on an invertebrate model, the Platyhelminth brown planarian. The animals exposed to a 10% sucrose solution in one context developed a conditioned place preference (CPP) which was subsequently extinguished in the absence of the rewarding agent. However, one exposure to sucrose per se sufficed to reinstate the CPP response, suggesting sucrose-induced CPP can be characterised as a standard Pavlovian response. The same training procedure led to the development of context-specific tolerance to the effects of sucrose. However, comparing animals treated with dopamine D1 antagonist (SCH-23390) with control animals showed that the establishment of CPP, but not the development of tolerance, is mediated by the dopamine reward system.
在啮齿动物中，蔗糖已被发现会引起类似成瘾的行为，例如产生耐受性和与消费时出现的线索相关联。此外，对蔗糖狂欢的神经化学反应与观察到的对可卡因等成瘾物质滥用的反应相当。这里报告的实验探讨了蔗糖对无脊椎动物模型——扁形动物棕色涡虫的影响。暴露于 10%蔗糖溶液中的动物在一种环境中产生了条件性位置偏好（CPP），随后在没有奖励物的情况下这种偏好被消除。然而，单次暴露于蔗糖本身足以恢复 CPP 反应，这表明蔗糖诱导的 CPP 可以被描述为一种标准的巴甫洛夫反应。相同的训练程序导致对蔗糖作用的特定环境的耐受性的发展。然而，与对照动物相比，用多巴胺 D1 拮抗剂（SCH-23390）处理的动物表明，CPP 的建立，而不是耐受性的发展，是由多巴胺奖励系统介导的。
