Fan Xinzhen, Yahia L'Hocine, Sacher Edward
Laboratoire d'Innovation et d'Analyse de Bioperformance, Département de Génie Mécanique, Polytechnique Montréal, CP 6079, Succursale C-V, Montréal, QC H3C 3A7, Canada.
Département de Génie Physique, Polytechnique Montréal, CP 6079, Succursale C-V, Montréal, QC H3C 3A7, Canada.
Biology (Basel). 2021 Feb 10;10(2):137. doi: 10.3390/biology10020137.
Microbes, including bacteria and fungi, easily form stable biofilms on many surfaces. Such biofilms have high resistance to antibiotics, and cause nosocomial and postoperative infections. The antimicrobial and antiviral behaviors of Ag and Cu nanoparticles (NPs) are well known, and possible mechanisms for their actions, such as released ions, reactive oxygen species (ROS), contact killing, the immunostimulatory effect, and others have been proposed. Ag and Cu NPs, and their derivative NPs, have different antimicrobial capacities and cytotoxicities. Factors, such as size, shape and surface treatment, influence their antimicrobial activities. The biomedical application of antimicrobial Ag and Cu NPs involves coating onto substrates, including textiles, polymers, ceramics, and metals. Because Ag and Cu are immiscible, synthetic AgCu nanoalloys have different microstructures, which impact their antimicrobial effects. When mixed, the combination of Ag and Cu NPs act synergistically, offering substantially enhanced antimicrobial behavior. However, when alloyed in Ag-Cu NPs, the antimicrobial behavior is even more enhanced. The reason for this enhancement is unclear. Here, we discuss these results and the possible behavior mechanisms that underlie them.
包括细菌和真菌在内的微生物很容易在许多表面形成稳定的生物膜。这种生物膜对抗生素具有高度抗性，并会导致医院感染和术后感染。银和铜纳米颗粒（NPs）的抗菌和抗病毒行为是众所周知的，并且已经提出了它们的作用机制，如释放离子、活性氧（ROS）、接触杀灭、免疫刺激作用等。银和铜纳米颗粒及其衍生纳米颗粒具有不同的抗菌能力和细胞毒性。尺寸、形状和表面处理等因素会影响它们的抗菌活性。抗菌银和铜纳米颗粒的生物医学应用包括涂覆在纺织品、聚合物、陶瓷和金属等基底上。由于银和铜互不相溶，合成的银铜纳米合金具有不同的微观结构，这会影响它们的抗菌效果。混合时，银和铜纳米颗粒的组合具有协同作用，抗菌性能大幅增强。然而，当形成银铜纳米颗粒合金时，抗菌性能会进一步增强。这种增强的原因尚不清楚。在此，我们讨论这些结果以及其背后可能的行为机制。
