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巴氏涂片检查用于宫颈癌筛查试验和避孕:来自 CONSTANCES 队列研究的数据分析。

Pap tests for cervical cancer screening test and contraception: analysis of data from the CONSTANCES cohort study.

机构信息

Department of General Practice, University of Poitiers, France: 3 rue de la Milétrie, 86000, Poitiers, France.

CESP Centre for Research in Epidemiology and Population Health, U1018, Gender, Sexuality and Health team, University of Paris-Saclay, University of Paris-Sud, UVSQ, Villejuif, France.

出版信息

BMC Cancer. 2019 Apr 5;19(1):317. doi: 10.1186/s12885-019-5477-8.

Abstract

BACKGROUND

In France, a Pap test for cervical cancer screening is recommended every three years for all sexually active women aged 25 to 65 years. Modes of contraception (any or no contraception, with or without a visit to a physician, and with or without a gynecological examination) may influence adhesion to screening: women who use intrauterine device (IUD) should be more up to date with their cervical cancer screening more often than those using other means of contraception. Our objectives were to analyze the association between modes of contraception and Pap tests for screening.

METHODS

This cross sectional study is based on the CONSTANCES cohort enabled us to include 16,764 women aged 25-50 years. The factors associated with adhesion to cervical cancer screening (defined by a report of a Pap test within the previous 3 years) was modeled by logistic regression. Missing data were imputed by using multiple imputations. The multivariate analyses were adjusted for sex life, social and demographic characteristics, and health status.

RESULTS

Overall, 11.2% (1875) of the women reported that they were overdue for Pap test screening. In the multivariate analysis there was no significant difference between women using an IUD and those pills or implant of pap test overdue ORa:0.9 CI [0.8-1.1], ORa 1.3 CI [0.7-2.7] respectively. Women not using contraceptives and those using non-medical contraceptives (condoms, spermicides, etc.) were overdue more often ORa: 2.6 CI [2.2-3.0] and ORa: 1.8 CI [1.6-2.1] respectively than those using an IUD.

CONCLUSION

Women seeing medical professionals for contraception are more likely to have Pap tests.

摘要

背景

在法国,建议所有 25 至 65 岁有性生活的女性每三年进行一次巴氏涂片检查,以筛查宫颈癌。避孕方式(无论是否避孕、是否看医生、是否做妇科检查)可能会影响筛查的依从性:使用宫内节育器(IUD)的女性比使用其他避孕方法的女性更需要经常进行宫颈癌筛查。我们的目的是分析避孕方式与巴氏涂片筛查之间的关系。

方法

本横断面研究基于 CONSTANCES 队列,纳入了 16764 名 25-50 岁的女性。通过逻辑回归模型分析了与宫颈癌筛查依从性相关的因素(定义为过去 3 年内有巴氏涂片检查报告)。使用多重插补法处理缺失数据。多变量分析调整了性生活、社会人口特征和健康状况。

结果

总体而言,11.2%(1875 名)的女性报告称她们的巴氏涂片检查已经逾期。在多变量分析中,使用 IUD 的女性与使用避孕药或植入物的女性相比,巴氏涂片检查逾期的比值比(ORa)为 0.9(95%CI:0.8-1.1),ORa 为 1.3(95%CI:0.7-2.7)。未使用避孕药具和使用非医学避孕药具(避孕套、杀精剂等)的女性逾期的比值比(ORa)分别为 2.6(95%CI:2.2-3.0)和 1.8(95%CI:1.6-2.1),高于使用 IUD 的女性。

结论

看医生进行避孕的女性更有可能进行巴氏涂片检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f1b5/6451274/cf1bbfb61632/12885_2019_5477_Fig1_HTML.jpg

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