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头颈部坏死性筋膜炎合并慢性骨髓炎:病例报告

Necrotizing fasciitis of the neck and head complicated with chronic osteomyelitis: Case report presentation.

作者信息

Wong-Chew Rosa María, Angel-Ambrocio Antonio H, Gomez-Murillo Sheila Yadira, Puente-Sanchez Angel, Fernandez-Sobrino Gerardo, Marhx-Bracho Alfonso, Marroquín-Yañez María de Lourdes

机构信息

Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico; Hospital Angeles del Pedregal, Mexico.

Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico.

出版信息

Int J Surg Case Rep. 2019;59:220-223. doi: 10.1016/j.ijscr.2019.03.025. Epub 2019 Mar 26.

Abstract

INTRODUCTION

Necrotizing fasciitis (NF) is a severe infectious condition associated with significant morbidity and mortality and characteristically has a higher incidence in adults; pediatric cases are very rare. In this case report we describe, the clinical presentation, management and outcome of a patient with necrotizing fasciitis of the neck and head complicated with chronic osteomyelitis.

PRESENTATION OF THE CASE

An 18 month-old, latin, male, diagnosed with rickets and Crouzon syndrome, twenty-four hours post- craniofacial remodeling surgery presented tissue edema, indurated skin and violaceous and well delimited lesions in the neck and head. The patient developed septic shock, acute osteomyelitis and infection of the cranial grafts. Multiple surgical lavages, debridation of the necrotic tissue and resection of the affected bone, in combination with multiple antibiotics, laboratory test methods, VAC therapy and hyperbaric oxygen were required for successful treatment and full recovery of the patient.

DISCUSSION

Although early antibiotic therapy and critical care are basic for the treatment of patients with NF, early aggressive surgical treatment is crucial for an adequate outcome. Adjuvant treatment for NF such as the Vacuum-assisted closure and the hyperbaric oxygen therapy are very useful to accelerate wound healing. Moreover, special laboratory test methods such as the checkerboard can be used to determine the adequate antimicrobial combination of drugs in the case of multi resistant organisms.

CONCLUSIONS

Early diagnosis, adequate antibiotic therapy and aggressive surgical debridement of the necrotic tissue combined with VAC and hyperbaric oxygen therapy played an important role in the successful treatment of NF.

摘要

引言

坏死性筋膜炎(NF)是一种严重的感染性疾病,具有较高的发病率和死亡率,其特征是在成人中发病率较高;儿科病例非常罕见。在本病例报告中,我们描述了一名患有头颈部坏死性筋膜炎并伴有慢性骨髓炎患者的临床表现、治疗及预后情况。

病例介绍

一名18个月大的拉丁裔男性,诊断为佝偻病和克鲁宗综合征,在颅面重塑手术后24小时出现组织水肿、皮肤硬结以及颈部和头部有紫罗兰色且边界清晰的病变。患者发展为感染性休克、急性骨髓炎和颅骨移植物感染。为使患者成功治愈并完全康复,需要多次手术冲洗、清除坏死组织、切除受累骨骼,并联合使用多种抗生素、实验室检测方法、负压伤口治疗(VAC)和高压氧治疗。

讨论

虽然早期抗生素治疗和重症监护是治疗NF患者 的基础,但早期积极的手术治疗对于取得良好预后至关重要。NF的辅助治疗,如负压伤口治疗和高压氧治疗,对加速伤口愈合非常有用。此外,在多重耐药菌的情况下,像棋盘法这样的特殊实验室检测方法可用于确定合适的抗菌药物联合使用方案。

结论

早期诊断、适当的抗生素治疗、积极的坏死组织手术清创,联合VAC和高压氧治疗,在NF的成功治疗中发挥了重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f3c6/6599410/0bec405eaafb/gr1.jpg

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