• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

聚（N-乙烯基己内酰胺）纳米凝胶具有抗 HIV-1 感染的抗病毒活性。

Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection.

机构信息

Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica. Av. Haya de la Torre esq. Av. Medina Allende, Córdoba, X5000HUA, Argentina.

CONICET, Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA). Av. Velez Sárfield 1611, Córdoba, X5000HUA, Argentina.

出版信息

Sci Rep. 2019 Apr 5;9(1):5732. doi: 10.1038/s41598-019-42150-9.

DOI:10.1038/s41598-019-42150-9
PMID:30952921
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6450967/
Abstract

Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.

摘要

刺激响应性纳米凝胶为开发用于生物医学应用的下一代制剂提供了有前景的视角。在这项工作中，通过改变单体和交联剂的浓度来合成聚（N-乙烯基己内酰胺）纳米凝胶。因此，首次提出了聚（N-乙烯基己内酰胺）纳米凝胶对 HIV-1 感染的抑制作用。具体而言，我们已经证明，在所合成的聚（N-乙烯基己内酰胺）纳米凝胶中，有一种纳米凝胶的初始浓度为 80mg 乙烯基己内酰胺和 4%的交联剂，对 HIV-1 感染具有抗病毒行为，因为这种纳米凝胶抑制 TZM.bl 靶细胞中的病毒复制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/33fb50b2a9df/41598_2019_42150_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/3e4a4b5a7481/41598_2019_42150_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/44f2f915fa25/41598_2019_42150_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/32ad092ec79e/41598_2019_42150_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/2120ec05fbac/41598_2019_42150_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/c8bb4183eb2b/41598_2019_42150_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/6d86437c2e10/41598_2019_42150_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/b2e70f9be05c/41598_2019_42150_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/33fb50b2a9df/41598_2019_42150_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/3e4a4b5a7481/41598_2019_42150_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/44f2f915fa25/41598_2019_42150_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/32ad092ec79e/41598_2019_42150_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/2120ec05fbac/41598_2019_42150_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/c8bb4183eb2b/41598_2019_42150_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/6d86437c2e10/41598_2019_42150_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/b2e70f9be05c/41598_2019_42150_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0f2a/6450967/33fb50b2a9df/41598_2019_42150_Fig8_HTML.jpg

相似文献

1
Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection.聚（N-乙烯基己内酰胺）纳米凝胶具有抗 HIV-1 感染的抗病毒活性。
Sci Rep. 2019 Apr 5;9(1):5732. doi: 10.1038/s41598-019-42150-9.
2
Multifunctional PVCL nanogels with redox-responsiveness enable enhanced MR imaging and ultrasound-promoted tumor chemotherapy.具有氧化还原响应性的多功能 PVCL 纳米凝胶可增强磁共振成像和超声促进的肿瘤化疗。
Theranostics. 2020 Mar 15;10(10):4349-4358. doi: 10.7150/thno.43402. eCollection 2020.
3
Dual responsive magnetic composite nanogels for thermo-chemotherapy.用于热化疗的双响应性磁性复合纳米凝胶
Colloids Surf B Biointerfaces. 2017 Jul 1;155:304-313. doi: 10.1016/j.colsurfb.2017.04.035. Epub 2017 Apr 19.
4
Glucose and Maltose Surface-Functionalized Thermoresponsive Poly(-Vinylcaprolactam) Nanogels.葡萄糖和麦芽糖表面功能化的温敏性聚（己内酯）纳米凝胶。
Biomacromolecules. 2020 Feb 10;21(2):955-965. doi: 10.1021/acs.biomac.9b01596. Epub 2020 Jan 22.
5
Influence of size, crosslinking degree and surface structure of poly(N-vinylcaprolactam)-based microgels on their penetration into multicellular tumor spheroids.聚（N-乙烯基己内酰胺）基微凝胶的尺寸、交联度和表面结构对其穿透多细胞肿瘤球体的影响。
Biomater Sci. 2019 Nov 1;7(11):4738-4747. doi: 10.1039/c9bm01132c. Epub 2019 Sep 10.
6
Synthesis and characterization of dual-responsive poly(N-vinylcaprolactam-co-N-methylolacrylamide) nanogels.双响应性聚（N-乙烯基己内酰胺-co-N-羟甲基丙烯酰胺）纳米凝胶的合成与表征
Des Monomers Polym. 2022 Jun 9;25(1):155-164. doi: 10.1080/15685551.2022.2086412. eCollection 2022.
7
Gadolinium-Loaded Poly(N-vinylcaprolactam) Nanogels: Synthesis, Characterization, and Application for Enhanced Tumor MR Imaging.载钆聚(N-乙烯基己内酰胺)纳米凝胶的合成、表征及其在增强肿瘤磁共振成像中的应用。
ACS Appl Mater Interfaces. 2017 Feb 1;9(4):3411-3418. doi: 10.1021/acsami.6b14219. Epub 2017 Jan 18.
8
Nano-in-nano enteric protein delivery system: coaxial Eudragit® L100-55 fibers containing poly(-vinylcaprolactam) nanogels.纳米-纳米肠内蛋白递药系统：含聚（乙烯己内酯）纳米凝胶的同轴 Eudragit® L100-55 纤维。
Biomater Sci. 2024 Jan 16;12(2):335-345. doi: 10.1039/d3bm01422c.
9
Cytotoxicity of thermosensitive polymers poly(N-isopropylacrylamide), poly(N-vinylcaprolactam) and amphiphilically modified poly(N-vinylcaprolactam).热敏聚合物聚（N-异丙基丙烯酰胺）、聚（N-乙烯基己内酰胺）及两亲性改性聚（N-乙烯基己内酰胺）的细胞毒性
Biomaterials. 2005 Jun;26(16):3055-64. doi: 10.1016/j.biomaterials.2004.09.008.
10
Temperature-responsive nanogel multilayers of poly(N-vinylcaprolactam) for topical drug delivery.聚（N-乙烯基己内酰胺）温敏纳米凝胶多层膜用于局部药物递送。
J Colloid Interface Sci. 2017 Nov 15;506:589-602. doi: 10.1016/j.jcis.2017.07.084. Epub 2017 Jul 22.

引用本文的文献

1
Fabrication and evaluation of pH/thermo dual responsive hydrogels as controlled ibuprofen sodium depot.pH/温度双响应水凝胶作为布洛芬钠控释制剂的制备与评价
Des Monomers Polym. 2024 Dec 30;28(1):1-15. doi: 10.1080/15685551.2024.2442118. eCollection 2025.
2
Recent advances in nanogels for drug delivery and biomedical applications.用于药物输送和生物医学应用的纳米凝胶的最新进展。
Biomater Sci. 2024 Nov 19;12(23):6006-6018. doi: 10.1039/d4bm00224e.
3
Aptamer-decorated nanocarriers for viral adsorption: A special look at COVID-19.

本文引用的文献

1
Rational design of dendritic thermoresponsive nanogels that undergo phase transition under endolysosomal conditions.在溶酶体条件下发生相变的树枝状热敏纳米凝胶的合理设计。
J Mater Chem B. 2017 Jan 28;5(4):866-874. doi: 10.1039/c6tb02001a. Epub 2017 Jan 11.
2
Acid degradable poly(vinylcaprolactam)-based nanogels with ketal linkages for drug delivery.用于药物递送的具有缩酮键的酸可降解聚（乙烯基己内酰胺）基纳米凝胶
J Mater Chem B. 2015 Jul 28;3(28):5824-5832. doi: 10.1039/c5tb00703h. Epub 2015 Jun 22.
3
Thermo/redox/pH-triple sensitive poly(N-isopropylacrylamide-co-acrylic acid) nanogels for anticancer drug delivery.
用于病毒吸附的适配体修饰纳米载体：对新冠病毒的特别关注
Mol Ther Nucleic Acids. 2024 Aug 15;35(3):102310. doi: 10.1016/j.omtn.2024.102310. eCollection 2024 Sep 10.
4
Is aromatic plants environmental health engineering (APEHE) a leverage point of the earth system?芳香植物环境健康工程（APEHE）是地球系统的一个杠杆点吗？
Heliyon. 2024 May 3;10(9):e30322. doi: 10.1016/j.heliyon.2024.e30322. eCollection 2024 May 15.
5
Nanoparticles as delivery vehicles for antiviral therapeutic drugs.纳米颗粒作为抗病毒治疗药物的递送载体。
Eng Regen. 2021;2:31-46. doi: 10.1016/j.engreg.2021.03.001. Epub 2021 Mar 24.
6
Biopolymer-Based Nanogel Approach in Drug Delivery: Basic Concept and Current Developments.基于生物聚合物的纳米凝胶药物递送方法：基本概念与当前进展
Pharmaceutics. 2023 Jun 2;15(6):1644. doi: 10.3390/pharmaceutics15061644.
7
Mesoporous Silica and Oligo (Ethylene Glycol) Methacrylates-Based Dual-Responsive Hybrid Nanogels.基于介孔二氧化硅和低聚（乙二醇）甲基丙烯酸酯的双响应杂化纳米凝胶
Nanomaterials (Basel). 2022 Oct 30;12(21):3835. doi: 10.3390/nano12213835.
8
Synthesis and Characterization of a Novel Dual-Responsive Nanogel for Anticancer Drug Delivery.新型双重响应性纳米胶束用于抗癌药物传递的合成与表征。
Oxid Med Cell Longev. 2022 Sep 19;2022:1548410. doi: 10.1155/2022/1548410. eCollection 2022.
9
Synthesis and characterization of dual-responsive poly(N-vinylcaprolactam-co-N-methylolacrylamide) nanogels.双响应性聚（N-乙烯基己内酰胺-co-N-羟甲基丙烯酰胺）纳米凝胶的合成与表征
Des Monomers Polym. 2022 Jun 9;25(1):155-164. doi: 10.1080/15685551.2022.2086412. eCollection 2022.
10
Biomedical polymers: synthesis, properties, and applications.生物医学聚合物：合成、性质及应用
Sci China Chem. 2022;65(6):1010-1075. doi: 10.1007/s11426-022-1243-5. Epub 2022 Apr 24.
用于抗癌药物递送的热/氧化还原/ pH三重敏感聚（N-异丙基丙烯酰胺-共-丙烯酸）纳米凝胶
J Mater Chem B. 2015 May 28;3(20):4221-4230. doi: 10.1039/c5tb00468c. Epub 2015 Apr 29.
4
Responsive crosslinked polymer nanogels for imaging and therapeutics delivery.用于成像和治疗递送的响应性交联聚合物纳米凝胶
J Mater Chem B. 2018 Jan 14;6(2):210-235. doi: 10.1039/c7tb02239e. Epub 2017 Dec 6.
5
Design, Synthesis and Architectures of Hybrid Nanomaterials for Therapy and Diagnosis Applications.用于治疗与诊断应用的混合纳米材料的设计、合成与结构
Polymers (Basel). 2018 May 14;10(5):527. doi: 10.3390/polym10050527.
6
Multifunctional Nanotherapeutics for the Treatment of neuroAIDS in Drug Abusers.用于治疗药物滥用者神经艾滋病的多功能纳米疗法。
Sci Rep. 2018 Aug 28;8(1):12991. doi: 10.1038/s41598-018-31285-w.
7
Antiretroviral Drugs Alter the Content of Extracellular Vesicles from HIV-1-Infected Cells.抗逆转录病毒药物改变了 HIV-1 感染细胞外囊泡的内容物。
Sci Rep. 2018 May 16;8(1):7653. doi: 10.1038/s41598-018-25943-2.
8
Generation of a Dual-Target, Safe, Inexpensive Microbicide that Protects Against HIV-1 and HSV-2 Disease.生成一种双重靶向、安全、廉价的杀菌剂，可预防 HIV-1 和 HSV-2 疾病。
Sci Rep. 2018 Feb 12;8(1):2786. doi: 10.1038/s41598-018-21134-1.
9
Vaginal bacteria modify HIV tenofovir microbicide efficacy in African women.阴道细菌会降低非洲女性使用替诺福韦艾滋病微凝胶的疗效。
Science. 2017 Jun 2;356(6341):938-945. doi: 10.1126/science.aai9383.
10
Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women.双汰芝阴道环预防女性艾滋病的安全性和有效性。
N Engl J Med. 2016 Dec 1;375(22):2133-2143. doi: 10.1056/NEJMoa1602046.