聚（N-乙烯基己内酰胺）纳米凝胶具有抗 HIV-1 感染的抗病毒活性。
Poly(N-vinylcaprolactam) Nanogels with Antiviral Behavior against HIV-1 Infection.
机构信息
Universidad Nacional de Córdoba, Facultad de Ciencias Químicas, Departamento de Química Orgánica. Av. Haya de la Torre esq. Av. Medina Allende, Córdoba, X5000HUA, Argentina.
CONICET, Instituto de Investigación y Desarrollo en Ingeniería de Procesos y Química Aplicada (IPQA). Av. Velez Sárfield 1611, Córdoba, X5000HUA, Argentina.
出版信息
Sci Rep. 2019 Apr 5;9(1):5732. doi: 10.1038/s41598-019-42150-9.
Stimuli-responsive nanogels offer promising perspectives for the development of next generation formulations for biomedical applications. In this work, poly(N-vinylcaprolactam) nanogels were synthesized varying the concentration of monomer and crosslinking agent. Thus, the inhibitory effect of poly(N-vinylcaprolactam) nanogels against HIV-1 infection is presented for the first time. In particular, we have demonstrated that one of the synthesized poly(N-vinylcaprolactam) nanogels with initial concentration of 80 mg of vinylcaprolactam and 4% of crosslinking agent shows antiviral behavior against HIV-1 infection since this nanogel inhibits the viral replication in TZM.bl target cells.
刺激响应性纳米凝胶为开发用于生物医学应用的下一代制剂提供了有前景的视角。在这项工作中，通过改变单体和交联剂的浓度来合成聚（N-乙烯基己内酰胺）纳米凝胶。因此，首次提出了聚（N-乙烯基己内酰胺）纳米凝胶对 HIV-1 感染的抑制作用。具体而言，我们已经证明，在所合成的聚（N-乙烯基己内酰胺）纳米凝胶中，有一种纳米凝胶的初始浓度为 80mg 乙烯基己内酰胺和 4%的交联剂，对 HIV-1 感染具有抗病毒行为，因为这种纳米凝胶抑制 TZM.bl 靶细胞中的病毒复制。
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