Cordeliers Research Center, INSERM, Sorbonne Université, USPC, Université Paris Diderot, F-75006, Paris, France.
Semin Immunopathol. 2019 Jul;41(4):531-545. doi: 10.1007/s00281-019-00736-5. Epub 2019 Apr 5.
Growing evidence suggests that components of the innate immune system play a crucial role in regulating metabolic homeostasis. Macrophages were the primary immune cells to be described in both the white adipose tissue and the pancreatic islets. Therein, their functions, beneficial or detrimental, are extending under steady state and in the context of obesity-induced type 2 diabetes. Other populations, including innate lymphoid cells, are emerging as key sentinels of metabolic tissues and privileged partners of macrophages. The present review will thus explore the phenotype and the role of innate immune cells in metabolic physiology and dysfunction. Discussion will tackle pending questions and future perspectives in the field of immunometabolism.
越来越多的证据表明，先天免疫系统的成分在调节代谢稳态方面起着至关重要的作用。巨噬细胞是最早在白色脂肪组织和胰岛中被描述的主要免疫细胞。在稳态和肥胖诱导的 2 型糖尿病的情况下，其功能（有益或有害）正在扩展。其他群体，包括先天淋巴细胞，正在成为代谢组织的关键哨兵和巨噬细胞的特权伙伴。因此，本综述将探讨先天免疫细胞在代谢生理学和功能障碍中的表型和作用。讨论将涉及免疫代谢领域的悬而未决的问题和未来展望。
