Multicenter National Mesothelioma Registry (MESONAT), Léon Bérard Cancer Center, Lyon, F-69008, France; FRANCIM Network, Toulouse, F-31000, France.
FRANCIM Network, Toulouse, F-31000, France; Digestive Cancer Registry, University Hospital, Caen, F-14033, France; INSERM U1086 « ANTICIPE », Caen University, F-14000, Caen, France.
Cancer Epidemiol. 2019 Jun;60:106-111. doi: 10.1016/j.canep.2019.03.014. Epub 2019 Apr 3.
Peritoneal malignant mesothelioma is a rare disease for which few population-based studies are available. The aim of this study was to describe the evolution of the incidence and survival of peritoneal malignant mesothelioma in France between 1989 and 2015, using data derived from the French network of cancer registries.
Age world-standardized incidence rates and overall survival were calculated using data from 16 French cancer registries. Log-linear Poisson regression analysis was used to estimate the average annual percentage change in incidence rates. Overall survival was performed using age-adjusted Cox proportional hazards model.
In French men, the incidence has increased quietly over the reporting period from 0.07 to 0.10 with a maximum of 0.16 per 100,000 persons-years in 2001-2003. For women, the increase in incidence has been lower than for men over the period 1989-2015, ranging from 0.04 to 0.11. A better prognosis was associated with a diagnosis made after 2000 (HR = 1.76; p = 0.013), the epithelioid histological type (p = 0.003), and the fact of being a woman, which has a 5-year risk of death half that of men (HR = 0.55; p = 0.001), regardless of age, diagnosis period or histology.
Our results are similar to those currently available for other countries. In France, peritoneal mesothelioma remains a rare and fatal cancer with a small increase in the incidence rate since 1989 and a median survival of 1 year; it seemed to develop equally in women and men over this period of time.
腹膜恶性间皮瘤是一种罕见疾病，目前可用的基于人群的研究较少。本研究旨在描述 1989 年至 2015 年间法国腹膜恶性间皮瘤的发病率和生存率的演变，使用来自法国癌症登记网络的数据。
使用来自 16 个法国癌症登记处的数据计算年龄标准化发病率和总生存率。使用对数线性泊松回归分析估计发病率的平均年变化百分比。使用年龄调整的 Cox 比例风险模型进行总体生存分析。
在法国男性中，报告期间发病率悄然上升，从 0.07 上升至 0.10，2001-2003 年期间最高为 0.16/10 万人年。对于女性，1989-2015 年期间发病率的上升低于男性，范围为 0.04 至 0.11。更好的预后与 2000 年后的诊断相关（HR=1.76；p=0.013）、上皮样组织学类型（p=0.003）和女性身份相关，女性的 5 年死亡风险是男性的一半（HR=0.55；p=0.001），无论年龄、诊断期或组织学类型如何。
我们的结果与其他国家目前的结果相似。在法国，腹膜间皮瘤仍然是一种罕见且致命的癌症，自 1989 年以来发病率略有上升，中位生存时间为 1 年；在这段时间内，它似乎在女性和男性中同样发展。
