Discipline of Pharmacy, School Health and Biomedical Sciences, RMIT University, Bundoora, VIC3083, Australia.
Discipline of Laboratory Medicine, School Health and Biomedical Sciences, RMIT University, Bundoora, VIC3083, Australia.
Drug Discov Today. 2019 Aug;24(8):1499-1509. doi: 10.1016/j.drudis.2019.03.028. Epub 2019 Apr 4.
Diabetic retinopathy (DR) is a microvascular complication of diabetes and is the leading cause of vision loss in people with diabetes. The current treatments do not target early stages of disease or impede disease progression. Therefore, the identification of new therapeutic targets, the development of novel therapies targeting early stages of the disease and accurate models that simulate pathological characteristics of this disorder are crucial. This review provides an overview of the pathological mechanisms underlying the development of DR, highlighting the recent advances in current and emerging treatments for DR.
糖尿病视网膜病变（DR）是糖尿病的一种微血管并发症，是导致糖尿病患者视力丧失的主要原因。目前的治疗方法不能针对疾病的早期阶段，也不能阻止疾病的进展。因此，确定新的治疗靶点，开发针对疾病早期阶段的新疗法，以及模拟该疾病病理特征的精确模型，是至关重要的。本文综述了 DR 发展的病理机制，强调了目前和新兴的 DR 治疗方法的最新进展。
