Leszczynski D, Ferry B, Schellekens H, van der Meide P H, Häyry P
J Exp Med. 1986 Nov 1;164(5):1470-7. doi: 10.1084/jem.164.5.1470.
A single injection of 10(5) U/kg of recombinant rat IFN-gamma increases the amount of tissue dendritic cells up to sixfold, and concomitantly induces the (capillary) endothelial cells to express class II MHC antigens. Both responses peak on the third day after IFN-gamma injection, and the antigen expression returns to basic levels on day 7. Simultaneous administration of 1 mg/kg/d of methylprednisolone entirely abolishes both responses. These observations demonstrate, for the first time, that IFN-gamma and steroids have antagonistic effects on class II MHC antigen presentation in tissue, and suggest that one immunosuppressive mechanism of glucocorticosteroids in organ transplantation is downregulation of graft antigenicity.
单次注射10(5) U/kg的重组大鼠干扰素-γ可使组织树突状细胞数量增加至六倍，并同时诱导（毛细血管）内皮细胞表达II类主要组织相容性复合体（MHC）抗原。这两种反应在注射干扰素-γ后的第三天达到峰值，抗原表达在第7天恢复到基础水平。同时给予1mg/kg/d的甲泼尼龙可完全消除这两种反应。这些观察结果首次证明，干扰素-γ和类固醇对组织中II类MHC抗原呈递具有拮抗作用，并表明糖皮质激素在器官移植中的一种免疫抑制机制是下调移植物抗原性。
