Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi 13488, Republic of Korea; College of Life Sciences Biotechnology, Korea University, 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Department of Biomedical Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, Gyeonggi 13488, Republic of Korea.
Colloids Surf B Biointerfaces. 2019 Jul 1;179:161-169. doi: 10.1016/j.colsurfb.2019.03.067. Epub 2019 Mar 29.
Poly(L-lactic acid) (PLLA) has been widely used as a promising biomaterial in biomedical applications due to its biodegradability and high mechanical strength. However, because of the inherent brittleness, low impact resistance, and weak thermal stability of PLLA, the modification process is usually required to utilize it for biomedical devices. Furthermore, acidic byproducts resulting from the hydrolysis of PLLA after implantation reduce the pH of the surrounding environment and cause inflammatory responses in the implanted area, leading to the failure of their clinical applications. To this end, here, we demonstrate a novel modification process for the PLLA composite with various functional additives, such as cis-aconitic anhydride (AA), triacetin (TA), isosorbide derivative (ISB), and/or Pluronic® F127 (F). The modified PLLA composite with TA and F (PLLA/TF) showed significantly improved elongation at break and Young's modulus and retained tensile strength. Moreover, incorporating magnesium hydroxide (MH) nanoparticles (PLLA/TFMH) significantly reduced acid-induced inflammation responses caused by the acidic degradation products of PLLA. Reduced plasma protein adsorption was observed in the PLLA/TFMH. These results suggest that the one step bulk modification of biodegradable PLLA using TA, F, and MH will have great potential in cardiovascular implant applications.
聚（L-乳酸）（PLLA）由于其可生物降解性和机械强度高，已被广泛用作生物医学应用中的一种有前途的生物材料。然而，由于 PLLA 的固有脆性、低抗冲击性和热稳定性差，通常需要对其进行改性处理，以将其用于生物医学设备。此外，PLLA 植入后水解产生的酸性副产物会降低周围环境的 pH 值，并在植入部位引起炎症反应，导致其临床应用失败。为此，我们在此展示了一种 PLLA 复合材料的新型改性工艺，该复合材料具有各种功能添加剂，如顺丁烯二酸酐（AA）、三醋酸甘油酯（TA）、异山梨醇衍生物（ISB）和/或 Pluronic® F127（F）。添加 TA 和 F（PLLA/TF）的改性 PLLA 复合材料的断裂伸长率和杨氏模量显著提高，同时保持拉伸强度。此外，加入氢氧化镁纳米粒子（PLLA/TFMH）可显著降低 PLLA 酸性降解产物引起的酸性诱导炎症反应。PLLA/TFMH 的血浆蛋白吸附减少。这些结果表明，使用 TA、F 和 MH 对可生物降解的 PLLA 进行一步本体改性，在心血管植入物应用中具有巨大的潜力。
