Department of Clinical Sciences, Division of Respiratory Medicine and Allergology, Lund University, Lund, Sweden.
Department of Psychology, University of Arizona Tucson, Arizona, USA.
BMJ Open Respir Res. 2019 Feb 12;6(1):e000370. doi: 10.1136/bmjresp-2018-000370. eCollection 2019.
Breathlessness, the subjective sensation of breathing discomfort, is common and appears in the daily life of people with cardiorespiratory diseases. Physicians often rely on patient's history based on symptom recall. The relation between recalled and experienced breathlessness is still poorly understood. This paper presents the protocol for a study primarily aimed at evaluating the relationship between experienced breathlessness and (1) recalled breathlessness and (2) predicted future breathlessness.
A mobile phone application will be used to collect data during daily life. Medically stable participants, ≥18 years of age with mean daily breathlessness of Numerical Rating Scale (NRS) 3/10 and able to use a mobile phone with internet will rate their breathlessness intensity on a 0-10 NRS prompted the user several times daily for 1 week. Participants will recall their breathlessness each day and week. Multivariable random effects regression models will be used for statistical analyses.
Results of the study will be submitted for publication in peer-reviewed journals and presented at relevant conferences.
This protocol describes a study aimed at investigating previously unknown areas of the experience and recall of breathlessness using a new method of data collection.
Prospectively registered with ClinicalTrials.gov (Nr: NCT03468205).
The study has received ethical approval from the Regional Ethical Review Board Lund (DNr 2017/149). After a general study information including that participation is entirely voluntary, participants will answer the eligibility criteria and be asked to consent to participate before entering the study questions. Written informed consent to participate will be obtained for participants in the clinical sub-cohort. Participation can be discontinued at the discretion of the participant in which case no further data will be collected.
呼吸困难是一种主观的呼吸不适感觉，在心肺疾病患者的日常生活中很常见。医生通常依赖于基于症状回忆的患者病史。回忆性呼吸困难与体验性呼吸困难之间的关系仍知之甚少。本文介绍了一项研究的方案，该研究主要旨在评估体验性呼吸困难与（1）回忆性呼吸困难和（2）预测未来呼吸困难之间的关系。
将使用移动电话应用程序在日常生活中收集数据。医学稳定的参与者，年龄≥18 岁，平均每日呼吸困难数字评定量表（NRS）评分为 3/10，能够使用带互联网的移动电话，将在每天提示用户多次的情况下，在 0-10 NRS 上对其呼吸困难强度进行评分，持续 1 周。参与者将每天和每周回忆自己的呼吸困难。将使用多变量随机效应回归模型进行统计分析。
研究结果将提交给同行评议期刊发表，并在相关会议上展示。
该方案描述了一项使用新的数据收集方法研究体验和回忆呼吸困难的未知领域的研究。
前瞻性在 ClinicalTrials.gov 注册（编号：NCT03468205）。
该研究已获得隆德地区伦理审查委员会的伦理批准（DNr 2017/149）。在提供了一般的研究信息，包括参与完全是自愿的之后，参与者将回答资格标准，并在进入研究问题之前被要求同意参与。将获得临床亚组参与者的书面知情同意书。参与者可以自行决定退出研究，在这种情况下，不会再收集更多数据。
