Department of Psychology, University of California, Los Angeles, Los Angeles, CA, USA.
Brain Research Institute, University of California, Los Angeles, Los Angeles, CA, USA.
Nat Neurosci. 2019 May;22(5):762-769. doi: 10.1038/s41593-019-0374-7. Epub 2019 Apr 8.
The value of an anticipated rewarding event is a crucial component of the decision to engage in its pursuit. But little is known of the networks responsible for encoding and retrieving this value. By using biosensors and pharmacological manipulations, we found that basolateral amygdala (BLA) glutamatergic activity tracks and mediates encoding and retrieval of the state-dependent incentive value of a palatable food reward. Projection-specific, bidirectional chemogenetic and optogenetic manipulations revealed that the orbitofrontal cortex (OFC) supports the BLA in these processes. Critically, the function of ventrolateral and medial OFC→BLA projections is doubly dissociable. Whereas lateral OFC→BLA projections are necessary and sufficient for encoding of the positive value of a reward, medial OFC→BLA projections are necessary and sufficient for retrieving this value from memory. These data reveal a new circuit for adaptive reward valuation and pursuit and provide insight into the dysfunction in these processes that characterizes myriad psychiatric diseases.
预期奖励事件的价值是决定参与追求该事件的关键组成部分。但是，负责编码和检索此价值的网络知之甚少。通过使用生物传感器和药理学操作，我们发现，外侧杏仁核（BLA）中的谷氨酸能活动可跟踪并介导可口食物奖励的状态相关激励价值的编码和检索。针对特定投射的双向化学遗传学和光遗传学操作表明，眶额皮质（OFC）支持这些过程中的 BLA。至关重要的是，腹外侧和内侧 OFC→BLA 投射的功能是双重可分离的。虽然外侧 OFC→BLA 投射对于奖励的正价值的编码是必需且充分的，但内侧 OFC→BLA 投射对于从记忆中检索此价值是必需且充分的。这些数据揭示了一种用于适应性奖励估值和追求的新回路，并深入了解了多种精神疾病中表征这些过程功能障碍的机制。
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