College of Humanities and Sciences, Nihon University, Sakurajosui, Setagaya-ku, Tokyo, 156-8550, Japan.
Biomaterials and Engineering, Tokyo Medical and Dental University, Surugadai, Kanda, 101-0062, Japan.
J Nat Med. 2019 Jun;73(3):648-652. doi: 10.1007/s11418-019-01304-9. Epub 2019 Apr 8.
A new crinine-type alkaloid crijaponine A (1), a new galanthamine-type alkaloid crijaponine B (2), and 11 known alkaloids-ungeremine (3), lycorine (4), 2-O-acetyllycorine (5), 1, 2-O-diacetyllycorine (6), (-)-crinine (7), 11-hydroxyvittatine (8), hamayne (9), (+)-epibuphanisine (10), crinamine (11), yemenine A (12), and epinorgalanthamine (13)-were isolated from the rhizome and fruits of Crinum asiaticum var. japonicum. The structural elucidation of the isolated compounds was performed by spectroscopic methods including 2D NMR. The isolated compounds were evaluated for cytotoxicity against HeLa and HL-60 cells lines and were tested for acetylcholinesterase inhibition activity.
从亚洲百合的根茎和果实中分离得到了一种新的石蒜碱型生物碱 crijaponine A（1）、一种新的加兰他敏型生物碱 crijaponine B（2）以及 11 种已知生物碱——乌药碱（3）、石蒜碱（4）、2-O-乙酰石蒜碱（5）、1,2-O-二乙酰石蒜碱（6）、(-)-石蒜碱（7）、11-羟基维替汀（8）、海鳗碱（9）、(+)-表布芬辛（10）、石蒜胺（11）、也门宁 A（12）和表加兰他敏（13）。通过二维 NMR 等光谱方法对分离得到的化合物进行了结构鉴定。对分离得到的化合物进行了对 HeLa 和 HL-60 细胞系的细胞毒性评价，并对乙酰胆碱酯酶抑制活性进行了测试。
