Renckens A L, Jansen M J, van Munster P J, Weemaes C M, Bakkeren J A
Clin Chem. 1986 Dec;32(12):2147-9.
We determined, immunonephelometrically, the ratio between the two types of light chains of immunoglobulins, kappa and lambda, in serum of 94 children, ages 0.4 to 14 years, with no manifest immunological disorders. Children with an abnormal protein pattern by immunoelectrophoresis show other values for this ratio than do children in this reference group. We also determined the ratios for children with IgA deficiency (I), juvenile rheumatic arthritis (II), and acute lymphoblastic leukemia (III). Children with I show the same kappa/lambda ratios as for the children in the reference group. Children with II also show the same mean kappa/lambda ratios, but a significantly wider range of ratios. In children with III, the ratio during chemotherapy is slightly depressed, significantly lower than after cessation of therapy. All groups--healthy children and patients--show an increase in kappa-chain-bearing immunoglobulins with age, but the concentration of lambda-chain-bearing immunoglobulins remains relatively constant.
我们采用免疫比浊法测定了94名年龄在0.4至14岁之间、无明显免疫紊乱的儿童血清中免疫球蛋白κ和λ两种轻链的比例。免疫电泳显示蛋白图谱异常的儿童，该比例与该参考组儿童的不同。我们还测定了患有IgA缺乏症（I组）、青少年风湿性关节炎（II组）和急性淋巴细胞白血病（III组）儿童的比例。I组儿童的κ/λ比例与参考组儿童相同。II组儿童的平均κ/λ比例也相同，但比例范围明显更宽。III组儿童在化疗期间该比例略有降低，显著低于治疗停止后。所有组——健康儿童和患者——均显示携带κ链的免疫球蛋白随年龄增加，但携带λ链的免疫球蛋白浓度相对保持恒定。
