Catauro Michelina, Tranquillo Elisabetta, Risoluti Roberta, Vecchio Ciprioti Stefano
Department of Engineering, University of Campania "Luigi Vanvitelli", Via Roma 29, I-81031 Aversa, Italy.
Department of Biochemistry, Biophysics and General Pathology, Medical School, University of Campania "Luigi Vanvitelli", Via L. De Crecchio 7, 80138 Naples, Italy.
Polymers (Basel). 2018 Jun 19;10(6):682. doi: 10.3390/polym10060682.
In this work, new phenol-based materials have been synthesized by the sol-gel method, in which different amounts of the phenolic antioxidant chlorogenic acid (CGA) (from 5 wt % to 20 wt %) were embedded in two different silica matrices: pure silica and silica-based hybrids materials, containing 50 wt % of polyethylene glycol (PEG). The incorporation of CGA in different sol-gel matrices might protect them from degradation, which could cause the loss of their properties. The two series of materials were chemically characterized by Fourier transform infrared (FTIR) spectroscopy. In addition, the thermal behavior of both series of materials containing CGA was studied by thermogravimetry under both air and inert N₂ flowing gas atmosphere. The bioactivity was evaluated by soaking the synthesized hybrids in a simulated body fluid, showing that the bioactivity of the silica matrix is not modified by the presence of PEG and CGA.
在本工作中，通过溶胶 - 凝胶法合成了新型酚基材料，其中不同量的酚类抗氧化剂绿原酸（CGA）（5重量％至20重量％）被嵌入两种不同的二氧化硅基质中：纯二氧化硅和含有50重量％聚乙二醇（PEG）的二氧化硅基杂化材料。将CGA掺入不同的溶胶 - 凝胶基质中可能会保护它们不被降解，否则可能会导致其性能丧失。通过傅里叶变换红外（FTIR）光谱对这两个系列的材料进行了化学表征。此外，通过热重分析法在空气和惰性N₂流动气体气氛下研究了含CGA的两个系列材料的热行为。通过将合成的杂化材料浸泡在模拟体液中来评估生物活性，结果表明二氧化硅基质的生物活性不受PEG和CGA存在的影响。
