Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Chongqing Key Laboratory of Biomedical Analysis, Chongqing Science & Technology Commission, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China.
Anal Chim Acta. 2019 Jul 31;1063:144-151. doi: 10.1016/j.aca.2019.02.047. Epub 2019 Mar 2.
The traditional synthesis methods of carbon dots (CDs) have some disadvantages of complicated operation and a large amount of energy consumption. To address these limitations, we synthesized yellow-green luminescent CDs at room temperature according to the principle of amine-aldehyde condensation in this work. This reaction is simple, economical, energy saving and is extremely consistent with the concept of green synthesis and sustainable development. In addition, studies have found that tetracycline hydrochloride (TC) can quench the fluorescence of the as-prepared CDs through Inner filter effect (IFE). The changes of the fluorescence intensity also have a good linear relationship with the concentration of TC in the range of 10.0-400.0 μM, and the detection limit is 6.0 μM. This method has been successfully used to determine the tetracycline content of tetracycline tablets. Finally, the interaction mechanism between TC and CDs was analyzed and discussed.
传统的碳点（CDs）合成方法存在操作复杂、能耗大等缺点。针对这些局限性，我们根据胺醛缩合原理在室温下合成了黄绿光致的 CDs。该反应简单、经济、节能，与绿色合成和可持续发展的理念极为一致。此外，研究发现盐酸四环素（TC）可以通过内滤效应（IFE）猝灭所制备的 CDs 的荧光。荧光强度的变化也与 TC 的浓度在 10.0-400.0 μM 范围内呈良好的线性关系，检测限为 6.0 μM。该方法已成功用于测定四环素片中四环素的含量。最后，分析和讨论了 TC 与 CDs 的相互作用机制。
