Centre Référent pour l'Anorexie et les Troubles du Comportement Alimentaire (CREATYON), Hospices Civils de Lyon, Lyon, France.
INSERM U1028, CNRS UMR5292, Université Claude Bernard Lyon 1, Centre de Recherche en Neurosciences de Lyon (CRNL), Equipe PSYR2 Centre Hospitalier Le Vinatier, Lyon, France.
Int J Obes (Lond). 2020 Jan;44(1):204-212. doi: 10.1038/s41366-019-0360-x. Epub 2019 Apr 9.
BACKGROUND/OBJECTIVE: In obesity there is growing evidence for common mechanism between food intake regulation and substance use disorders, especially more attentional bias and less cognitive control. In the present study we investigated whether severely obese subjects with or without disordered eating exhibit electroencephalographic (EEG) event-related potential (ERP) modifications as observed in substance abusers.
SUBJECTS/METHODS: A total of 90 women were included; 30 in the normal-weight (NW) group (18.5 < BMI < 24.5 kg/m; no food disinhibition or restriction on the Three-Factor Eating Questionnaire) and 60 participants with BMI ≥ 35 kg/m were separated into two groups (n = 30): without food disinhibition (disinhibition score ≤8; ObFD- group) and with food disinhibition (score >8; ObFD+). Clinical and metabolic parameters as well as compartmental aspects (Eating Disorders Inventory-2, EDI-2) were assessed. Participants underwent an ERP recording with an auditory oddball paradigm.
The mean ± SD P300 amplitudes in Pz were significantly (p < 0.05) lower in ObFD- (12.4 ± 4.6) and ObFD+ (12.5 ± 4.4) groups than in the NW group (15.8 ± 5.9). The mean ± SD N200 amplitude in Cz was significantly lower in the ObFD- group (-2.0 ± 5.4) than in the NW group (-5.2 ± 4.2 vs; p = 0.035). N200 Cz amplitude was correlated with EDI-2 Binge eating risk score (ρ = 0.331; p = 0.01), EDI-2 Body Dissatisfaction score (ρ = 0.351; p = 0.007), and Drive for Thinness score (ρ = 0.26; p = 0.05).
The present study provides evidence for reduction of P300 and N200 amplitude in obese women and that N200 amplitude may be related to more disordered eating and eating disorder risk. This leads to consider attentional bias and response inhibition as core mechanisms in obesity and as possible targets for new therapeutic strategy.
背景/目的：在肥胖症中，越来越多的证据表明食物摄入调节和物质使用障碍之间存在共同的机制，特别是注意力偏向和认知控制减少。在本研究中，我们研究了有无饮食障碍的严重肥胖患者是否表现出与物质滥用者相似的脑电图（EEG）事件相关电位（ERP）改变。
受试者/方法：共纳入 90 名女性，其中 30 名属于正常体重组（18.5 < BMI < 24.5 kg/m；3 因素饮食问卷无食物抑制或限制），60 名参与者的 BMI ≥ 35 kg/m 被分为两组（n = 30）：无食物抑制（抑制评分≤8；ObFD-组）和有食物抑制（评分>8；ObFD+组）。评估了临床和代谢参数以及分区方面（饮食障碍问卷-2，EDI-2）。参与者接受了听觉Oddball 范式的 ERP 记录。
Pz 处的平均 P300 振幅在 ObFD-（12.4 ± 4.6）和 ObFD+（12.5 ± 4.4）组中显著（p < 0.05）低于 NW 组（15.8 ± 5.9）。Cz 处的平均 N200 振幅在 ObFD-组中明显低于 NW 组（-2.0 ± 5.4 vs. -5.2 ± 4.2；p = 0.035）。Cz 处的 N200 振幅与 EDI-2 暴食风险评分（ρ=0.331；p=0.01）、EDI-2 身体不满评分（ρ=0.351；p=0.007）和瘦身驱动评分（ρ=0.26；p=0.05）呈正相关。
本研究为肥胖女性 P300 和 N200 振幅降低提供了证据，并且 N200 振幅可能与更紊乱的饮食和饮食障碍风险有关。这使得我们将注意力偏向和反应抑制视为肥胖症的核心机制，并作为新的治疗策略的可能靶点。
