Emotion and Development Branch,National Institute of Mental Health,Bethesda, MD,USA.
Dev Psychopathol. 2019 Aug;31(3):859-869. doi: 10.1017/S0954579419000300. Epub 2019 Apr 10.
While emotional dysregulation is a broad construct, the current paper adopts a narrow approach to facilitate translational neuroscience research on pediatric anxiety. The paper first presents data on an adapted version of the antisaccade task and then integrates these data into a research framework. Data on an adapted version of the antisaccade task were collected in 57 youth, including 35 seeking treatment for an anxiety disorder. Associations were examined between performance on the antisaccade task and (a) age, (b) performance on other cognitive-control tasks (i.e., the stop-signal delay and flanker tasks), and (c) level of anxiety symptoms. Better performance on the antisaccade task occurred in older relative to younger subjects and correlated with better performance on the flanker task. Across the 57 youth, higher levels of anxiety correlated with shorter latency for correct antisaccades. These data can be placed within a three-step framework for translational neuroscience research. In the first step, a narrow index of emotion dysregulation is targeted. In the second step, this narrow index is linked to other correlated indicators of the same underlying narrow latent construct. In the third and final step, associations are examined with clinical outcomes and response to treatment.
虽然情绪调节障碍是一个广泛的概念，但本文采用狭义的方法来促进儿科焦虑症的转化神经科学研究。本文首先介绍了反扫视任务改编版的数据，然后将这些数据整合到一个研究框架中。反扫视任务改编版的数据是在 57 名年轻人中收集的，其中 35 名年轻人因焦虑症寻求治疗。研究考察了反扫视任务的表现与（a）年龄、（b）其他认知控制任务（即停止信号延迟和侧翼任务）的表现以及（c）焦虑症状水平之间的关系。与年轻组相比，年龄较大的组在反扫视任务中的表现更好，并且与侧翼任务的表现更好相关。在 57 名年轻人中，更高的焦虑水平与正确反扫视的潜伏期更短相关。这些数据可以放在转化神经科学研究的三步框架内。在第一步中，目标是一个狭窄的情绪失调指数。在第二步中，将这个狭窄的指标与同一潜在狭窄结构的其他相关指标联系起来。在第三步也是最后一步中，研究与临床结果和治疗反应的关联。
