Beving H, Kristensson J, Malmgren R, Olsson U, Schmidt S, Svensson J
J Chromatogr. 1986 Oct 31;382:67-77. doi: 10.1016/s0378-4347(00)83505-7.
An improved method for the determination of the regeneration time of human platelets is presented. The platelet-megakaryocyte regeneration times of painters exposed to organic solvents (n = 5; age range 23-48 years) were compared with a reference group (n = 5; age range 23-46 years) not occupationally exposed to solvents. After purification and extraction of the samples, they were analysed by high-performance liquid chromatography. The results showed that the painters have a shorter regeneration time (range 4.4-5.2 days) than the reference group (range 5.2-6.9 days) and indicate that solvent exposure may be associated with an increase in platelet turnover in man.
本文提出了一种改进的测定人类血小板再生时间的方法。将接触有机溶剂的油漆工（n = 5；年龄范围23 - 48岁）的血小板 - 巨核细胞再生时间与未职业性接触溶剂的参照组（n = 5；年龄范围23 - 46岁）进行比较。样品经过纯化和提取后，采用高效液相色谱法进行分析。结果表明，油漆工的再生时间（范围为4.4 - 5.2天）比参照组（范围为5.2 - 6.9天）短，这表明接触溶剂可能与人的血小板周转率增加有关。
