Wahlich John, Orlu Mine, Mair Alpana, Stegemann Sven, van Riet-Nales Diana
Academy of Pharmaceutical Sciences, 4 Heydon Road, Great Chishill, Royston, Herts SG8 8SR, UK.
Department of Pharmaceutics, School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Pharmaceutics. 2019 Apr 9;11(4):172. doi: 10.3390/pharmaceutics11040172.
A meeting organised by the Academy of Pharmaceutical Sciences focussed on the challenges of developing medicines for older adults. International experts discussed the complexity introduced by polypharmacy and multiple morbidities and how the risk⁻benefit ratio of a medicine changes as an individual ages. The way in which regulatory authorities are encouraging the development of age-appropriate medicines was highlighted. Examples were provided of the difficulties faced by the older population with some medicinal products and suggestions given as to how the pharmaceutical scientist can build the requirements of the older population into their development of new medicines, as well as improvements to existing ones.
由药物科学研究院组织的一次会议聚焦于为老年人开发药物所面临的挑战。国际专家们讨论了多重用药和多种疾病带来的复杂性，以及药物的风险效益比如何随着个体年龄的增长而变化。会议强调了监管机构鼓励开发适合不同年龄段药物的方式。会上列举了老年人群在使用某些药品时所面临的困难，并就药物科学家如何在新药研发以及现有药物改进过程中将老年人群的需求考虑在内提出了建议。
