Miguel Sónia P, Ribeiro Maximiano P, Coutinho Paula, Correia Ilídio J
CICS-UBI-Centro de Investigação em Ciências da Saúde, Universidade da Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal.
UDI-IPG-Unidade de Investigação para o Desenvolvimento do Interior, Instituto Politécnico da Guarda, 6300-559 Guarda, Portugal.
Polymers (Basel). 2017 May 21;9(5):183. doi: 10.3390/polym9050183.
Today, none of the wound dressings available on the market is fully capable of reproducing all the features of native skin. Herein, an asymmetric electrospun membrane was produced to mimic both layers of skin. It comprises a top dense layer (manufactured with polycaprolactone) that was designed to provide mechanical support to the wound and a bottom porous layer (composed of chitosan and Aloe Vera) aimed to improve the bactericidal activity of the membrane and ultimately the healing process. The results obtained revealed that the produced asymmetric membranes displayed a porosity, wettability, as well as mechanical properties similar to those presented by the native skin. Fibroblast cells were able to adhere, spread, and proliferate on the surface of the membranes and the intrinsic structure of the two layers of the membrane is capable of avoiding the invasion of microorganisms while conferring bioactive properties. Such data reveals the potential of these asymmetric membranes, in the near future, to be applied as wound dressings.
如今，市面上现有的伤口敷料都无法完全重现天然皮肤的所有特性。在此，制备了一种不对称电纺膜来模拟皮肤的两层结构。它包括一个顶部致密层（由聚己内酯制成），旨在为伤口提供机械支撑，以及一个底部多孔层（由壳聚糖和芦荟组成），旨在提高膜的杀菌活性并最终促进愈合过程。所获得的结果表明，制备的不对称膜具有与天然皮肤相似的孔隙率、润湿性以及机械性能。成纤维细胞能够在膜表面粘附、铺展和增殖，并且膜的两层固有结构能够避免微生物的侵入，同时赋予生物活性特性。这些数据揭示了这些不对称膜在不久的将来用作伤口敷料的潜力。
